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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Two cDNAs coding for histamine-gated ion channels in D. melanogaster.

Histamine, a neurotransmitter and neuroregulatory compound in diverse species, serves as the neurotransmitter of photoreceptors in insects and other arthropods by directly activating a chloride channel. By systematic expression screening of novel putative ligand-gated anion channels, we identified two cDNAs (DM-HisCl- alpha 1 and-alpha 2) coding for putative histamine-gated chloride channels by functional expression in Xenopus laevis oocytes. DM-HisCl- alpha 1 mRNA localizes in the lamina region of the Drosophila eye, supporting the idea that DM-HisCl- alpha 1 may be a neurotransmitter receptor for histamine in the visual system.[1]

References

  1. Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann, G., Pusch, H., Hovemann, B.T., Hatt, H. Nat. Neurosci. (2002) [Pubmed]
 
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