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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla.

Four new alkaloids (1-4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1-4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 microg/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC(50) values of 1.1, 0.66, and 2.5 microg/mL, respectively.[1]

References

  1. Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla. Tsukamoto, S., Tane, K., Ohta, T., Matsunaga, S., Fusetani, N., van Soest, R.W. J. Nat. Prod. (2001) [Pubmed]
 
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