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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Murphy, B. et al.

Murphy, Georgiou, Machet, Hill, McRae,

Factor H-related protein-5: a novel component of human glomerular immune deposits.

Factor H-related protein-5 (FHR-5) is a newly described human plasma protein with structural similarities to human factor H and the four other recently described factor H-related proteins. Unlike the other factor H-related proteins, FHR-5 was initially identified at the protein, rather than complementary DNA, level in studies of glomerular immune deposit composition. To determine the incidence and pattern of detection of FHR-5 in human renal biopsy specimens, a prospective study of 100 consecutive biopsies was performed using anti-FHR-5 monoclonal antibody and indirect immunofluorescence. The pattern of FHR-5 deposition is very similar to that of other complement components, C3 and SC5b-9. It is detected in all complement-containing glomerular immune deposits and has a pattern of extraglomerular deposition similar to that of other complement components. This study shows FHR-5 to be strongly associated with glomerular complement deposition and suggests a role in complement activation or regulation. It may be an important mediator of glomerular disease.[1]

References

Factor H-related protein-5: a novel component of human glomerular immune deposits. Murphy, B., Georgiou, T., Machet, D., Hill, P., McRae, J. Am. J. Kidney Dis. (2002) [Pubmed]

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