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MeSH Review

Complement Activation

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Disease relevance of Complement Activation


Psychiatry related information on Complement Activation


High impact information on Complement Activation

  • Upon recognition of the infectious agent, MBL and the ficolins initiate the lectin pathway of complement activation through attached serine proteases (MASPs), whereas SP-A and SP-D rely on other effector mechanisms: direct opsonization, neutralization, and agglutination [7].
  • CD21 binds the C3d fragment of activated C3 that becomes covalently attached to targets of complement activation, and CD19 co-stimulates signaling through the antigen receptor, membrane immunoglobulin [8].
  • Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster [9].
  • A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity [10].
  • Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans [10].

Chemical compound and disease context of Complement Activation


Biological context of Complement Activation


Anatomical context of Complement Activation


Associations of Complement Activation with chemical compounds


Gene context of Complement Activation


Analytical, diagnostic and therapeutic context of Complement Activation


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  35. Recent advances in xenotransplantation. Sandrin, M.S., McKenzie, I.F. Curr. Opin. Immunol. (1999) [Pubmed]
  36. Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor. Nicholson-Weller, A., March, J.P., Rosenfeld, S.I., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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  38. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection. Miyatake, T., Sato, K., Takigami, K., Koyamada, N., Hancock, W.W., Bazin, H., Latinne, D., Bach, F.H., Soares, M.P. J. Immunol. (1998) [Pubmed]
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