The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Complement Activation

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Complement Activation

 

Psychiatry related information on Complement Activation

 

High impact information on Complement Activation

  • Upon recognition of the infectious agent, MBL and the ficolins initiate the lectin pathway of complement activation through attached serine proteases (MASPs), whereas SP-A and SP-D rely on other effector mechanisms: direct opsonization, neutralization, and agglutination [7].
  • CD21 binds the C3d fragment of activated C3 that becomes covalently attached to targets of complement activation, and CD19 co-stimulates signaling through the antigen receptor, membrane immunoglobulin [8].
  • Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster [9].
  • A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity [10].
  • Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans [10].
 

Chemical compound and disease context of Complement Activation

 

Biological context of Complement Activation

 

Anatomical context of Complement Activation

 

Associations of Complement Activation with chemical compounds

 

Gene context of Complement Activation

 

Analytical, diagnostic and therapeutic context of Complement Activation

References

  1. Active anaphylaxis in IgE-deficient mice. Oettgen, H.C., Martin, T.R., Wynshaw-Boris, A., Deng, C., Drazen, J.M., Leder, P. Nature (1994) [Pubmed]
  2. Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells. Tsuji, R.F., Geba, G.P., Wang, Y., Kawamoto, K., Matis, L.A., Askenase, P.W. J. Exp. Med. (1997) [Pubmed]
  3. Increased C5a receptor expression in sepsis. Riedemann, N.C., Guo, R.F., Neff, T.A., Laudes, I.J., Keller, K.A., Sarma, V.J., Markiewski, M.M., Mastellos, D., Strey, C.W., Pierson, C.L., Lambris, J.D., Zetoune, F.S., Ward, P.A. J. Clin. Invest. (2002) [Pubmed]
  4. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. Atkinson, C., Song, H., Lu, B., Qiao, F., Burns, T.A., Holers, V.M., Tsokos, G.C., Tomlinson, S. J. Clin. Invest. (2005) [Pubmed]
  5. Plasmin-mediated activation of contact system in response to pharmacological thrombolysis. Ewald, G.A., Eisenberg, P.R. Circulation (1995) [Pubmed]
  6. 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. Hays, S.J., Caprathe, B.W., Gilmore, J.L., Amin, N., Emmerling, M.R., Michael, W., Nadimpalli, R., Nath, R., Raser, K.J., Stafford, D., Watson, D., Wang, K., Jaen, J.C. J. Med. Chem. (1998) [Pubmed]
  7. Collections and ficolins: humoral lectins of the innate immune defense. Holmskov, U., Thiel, S., Jensenius, J.C. Annu. Rev. Immunol. (2003) [Pubmed]
  8. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Fearon, D.T., Carroll, M.C. Annu. Rev. Immunol. (2000) [Pubmed]
  9. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Liszewski, M.K., Post, T.W., Atkinson, J.P. Annu. Rev. Immunol. (1991) [Pubmed]
  10. Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans. Murthy, K.H., Smith, S.A., Ganesh, V.K., Judge, K.W., Mullin, N., Barlow, P.N., Ogata, C.M., Kotwal, G.J. Cell (2001) [Pubmed]
  11. Evaluation of thromboxane production and complement activation during myocardial ischemia in patients with angina pectoris. Montalescot, G., Drobinski, G., Maclouf, J., Maillet, F., Salloum, J., Ankri, A., Kazatchkine, M., Eugène, L., Thomas, D., Grosgogeat, Y. Circulation (1991) [Pubmed]
  12. Plasma levels of the chemokines monocyte chemotactic proteins-1 and -2 are elevated in human sepsis. Bossink, A.W., Paemen, L., Jansen, P.M., Hack, C.E., Thijs, L.G., Van Damme, J. Blood (1995) [Pubmed]
  13. Effect of heparin on complement activation and lysis of paroxysmal nocturnal hemoglobinuria (PNH) red cells. Logue, G.L. Blood (1977) [Pubmed]
  14. Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120. Süsal, C., Kirschfink, M., Kröpelin, M., Daniel, V., Opelz, G. Blood (1996) [Pubmed]
  15. Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). Jansen, J.H., Høgåsen, K., Mollnes, T.E. Am. J. Pathol. (1993) [Pubmed]
  16. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, K.B. J. Exp. Med. (2002) [Pubmed]
  17. Mediation of increased vascular permeability after complement activation. Histamine-independent action of rabbit C5a. Williams, T.J., Jose, P.J. J. Exp. Med. (1981) [Pubmed]
  18. In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. Lubinski, J., Wang, L., Mastellos, D., Sahu, A., Lambris, J.D., Friedman, H.M. J. Exp. Med. (1999) [Pubmed]
  19. cis and trans elements differ among mouse strains with high and low extrahepatic complement factor B gene expression. Garnier, G., Ault, B., Kramer, M., Colten, H.R. J. Exp. Med. (1992) [Pubmed]
  20. Generation of leukotrienes by human monocytes upon stimulation of their beta-glucan receptor during phagocytosis. Czop, J.K., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  21. Protective effects of C5a blockade in sepsis. Czermak, B.J., Sarma, V., Pierson, C.L., Warner, R.L., Huber-Lang, M., Bless, N.M., Schmal, H., Friedl, H.P., Ward, P.A. Nat. Med. (1999) [Pubmed]
  22. Quantitative variations of the C3b/C4b receptor (CR1) in human erythrocytes are controlled by genes within the regulator of complement activation (RCA) gene cluster. Rodriguez de Cordoba, S., Rubinstein, P. J. Exp. Med. (1986) [Pubmed]
  23. Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. Schiller, B., He, C., Salant, D.J., Lim, A., Alexander, J.J., Quigg, R.J. J. Exp. Med. (1998) [Pubmed]
  24. Host resistance to lipopolysaccharides in the pathogenesis of multiple sclerosis and membranoproliferative glomerulonephritis. Back, U., Moller, B.B., Bog-Hansen, T.C. Lancet (1976) [Pubmed]
  25. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Huang, J., Kim, L.J., Mealey, R., Marsh, H.C., Zhang, Y., Tenner, A.J., Connolly, E.S., Pinsky, D.J. Science (1999) [Pubmed]
  26. Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Weisman, H.F., Bartow, T., Leppo, M.K., Marsh, H.C., Carson, G.R., Concino, M.F., Boyle, M.P., Roux, K.H., Weisfeldt, M.L., Fearon, D.T. Science (1990) [Pubmed]
  27. C1q--how many functions? How many receptors? Eggleton, P., Reid, K.B., Tenner, A.J. Trends Cell Biol. (1998) [Pubmed]
  28. Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Mellor, A.L., Sivakumar, J., Chandler, P., Smith, K., Molina, H., Mao, D., Munn, D.H. Nat. Immunol. (2001) [Pubmed]
  29. A critical role for murine complement regulator crry in fetomaternal tolerance. Xu, C., Mao, D., Holers, V.M., Palanca, B., Cheng, A.M., Molina, H. Science (2000) [Pubmed]
  30. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J.M., Kraus, D., Hollmann, T.J., Casali, P., Caroll, M.C., Wetsel, R.A., Lambris, J.D., Holers, V.M., Salmon, J.E. J. Clin. Invest. (2003) [Pubmed]
  31. Cytokine-induced neutrophil chemoattractant mediates neutrophil influx in immune complex glomerulonephritis in rat. Wu, X., Wittwer, A.J., Carr, L.S., Crippes, B.A., DeLarco, J.E., Lefkowith, J.B. J. Clin. Invest. (1994) [Pubmed]
  32. Interleukin 4 acts as an inducer of decay-accelerating factor gene expression in human intestinal epithelial cells. Andoh, A., Fujiyama, Y., Sumiyoshi, K., Sakumoto, H., Bamba, T. Gastroenterology (1996) [Pubmed]
  33. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. Feinberg, H., Uitdehaag, J.C., Davies, J.M., Wallis, R., Drickamer, K., Weis, W.I. EMBO J. (2003) [Pubmed]
  34. Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum. Schlesinger, L.S., Horwitz, M.A. J. Clin. Invest. (1990) [Pubmed]
  35. Recent advances in xenotransplantation. Sandrin, M.S., McKenzie, I.F. Curr. Opin. Immunol. (1999) [Pubmed]
  36. Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor. Nicholson-Weller, A., March, J.P., Rosenfeld, S.I., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  37. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Sun, X., Funk, C.D., Deng, C., Sahu, A., Lambris, J.D., Song, W.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  38. Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection. Miyatake, T., Sato, K., Takigami, K., Koyamada, N., Hancock, W.W., Bazin, H., Latinne, D., Bach, F.H., Soares, M.P. J. Immunol. (1998) [Pubmed]
 
WikiGenes - Universities