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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1 is a UV damage endonuclease.

An in vitro transposition system, developed to facilitate gene disruption in Deinococcus radiodurans R1, has been used to inactivate the gene designated dr1819 in uvrA-1(+) and uvrA-1 backgrounds. dr1819 encodes a protein with homology to a UV DNA damage endonuclease expressed by Schizosaccharomyces pombe. Interruption of dr1819 greatly sensitizes the uvrA-1 strain but not the uvrA-1(+) strain to UV light, indicating that the dr1819 gene product is a component in a DNA repair pathway that can compensate for the loss of nucleotide excision repair in this species. Clones of dr1819 will restore UV resistance to UVS78, a uvrA-1 uvsE strain, indicating that dr1819 and uvsE are the same locus.[1]

References

  1. Genetic evidence that the uvsE gene product of Deinococcus radiodurans R1 is a UV damage endonuclease. Earl, A.M., Rankin, S.K., Kim, K.P., Lamendola, O.N., Battista, J.R. J. Bacteriol. (2002) [Pubmed]
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