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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.

We showed in human melanoma cells tryptophan hydroxylase ( TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.[1]

References

  1. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. Slominski, A., Semak, I., Pisarchik, A., Sweatman, T., Szczesniewski, A., Wortsman, J. FEBS Lett. (2002) [Pubmed]
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