Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback.
In the root epidermis of Arabidopsis, hair and nonhair cell types are specified in a distinct position-dependent pattern. Here, we show that transcriptional feedback loops between the WEREWOLF ( WER), CAPRICE ( CPC), and GLABRA2 ( GL2) genes help to establish this pattern. Positional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cells located in a particular position (N) and adoption of the nonhair fate. The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER, GL2, and its own gene in the alternative position (H) to induce the hair fate. These results provide a molecular genetic framework for understanding the determination of a cell-type pattern in plants.[1]References
- Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback. Lee, M.M., Schiefelbein, J. Plant Cell (2002) [Pubmed]
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