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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, myb

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Disease relevance of Genes, myb

  • Murine hematopoietic cells can be transformed in vitro by recombinant retroviruses that express the myb oncogene, and hematopoietic growth factor (HGF)-dependent myeloid cell lines can be derived from these transformed primary cells [1].
  • Three double negative (BoCD4-, BoCD8-) bovine T cell lines, BTL-PC3, BLT2, and Pr2181, which have been established from bovine lymphosarcomas, were examined for expression and molecular function of bovine c-myb genes [2].
  • We investigated the subcellular localization of Myb proteins in cultured non-synchronized insect cells transfected with recombinant baculoviruses overexpressing either v-myb oncogene or c-myb proto-oncogene [3].
  • In two cases of childhood T-ALL, both carrying a t(6;7)(q23;q32 through 36), split FISH signals were produced by adjacent PAC, mapping the breakpoints to within an approximately 150 Kb region containing the genes c-MYB and AHI1 [4].

High impact information on Genes, myb


Biological context of Genes, myb


Anatomical context of Genes, myb

  • To study the extent of human DNA coding sequences that constitute the myb gene homologue, c-myb (human), probes spanning about 30 kbp were prepared from the clones and used to study transcription in a human hematopoietic cell line (MOLT-4) [14].
  • Here we show that mutations in the c-Myb gene cause a myeloproliferative syndrome and supraphysiological expansion of megakaryocyte and platelet production in the absence of thrombopoietin signaling [15].
  • Here, we present the isolation of DUO1, a novel R2R3 MYB gene of Arabidopsis, as the first gene shown to control male gamete formation in plants [16].
  • Cooperation between the H-ras oncogene and a truncated derivative of the v-myb oncogene in transformation of hamster embryo fibroblasts [17].

Associations of Genes, myb with chemical compounds


Gene context of Genes, myb

  • A microRNA target sequence is present in the MYB genes, and mutating this sequence in the MYB33:GUS fusion results in an expanded expression pattern, in tissues similar to that observed in the promoter-GUS lines, implying that the microRNA target sequence is restricting MYB33 expression [23].
  • Cell sorting experiments demonstrated that only GFP(-) ECs could give rise to HPCs and preferentially expressed Runx1 and c-Myb genes that are required for the definitive hematopoiesis [24].
  • The mammalian myb gene family contains two members in addition to c-myb, A-myb, and B-myb [25].
  • The v-myb gene carried by avian myeloblastosis virus has a transforming capacity, but the c-myb proto-oncogene does not [26].
  • DUO1 appears to be evolutionarily conserved in several plant species and defines a new subfamily of pollen-specific MYB genes [16].

Analytical, diagnostic and therapeutic context of Genes, myb

  • Molecular cloning of the myb gene and analysis of the MYB protein expressed in the HL-60 variant cells established that the lack of binding did not result from a structural alteration of MYB in these cells [27].


  1. Differentiation state and responses to hematopoietic growth factors of murine myeloid cells transformed by myb. Gonda, T.J., Macmillan, E.M., Townsend, P.V., Hapel, A.J. Blood (1993) [Pubmed]
  2. A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells. Ishiguro, N., Ohzono, T., Shinagawa, T., Horiuchi, M., Shinagawa, M. J. Biol. Chem. (1994) [Pubmed]
  3. Overexpression of v-myb oncogene or c-myb proto-oncogene in insect cells: characterization of newly induced nucleolus-like structures accumulating Myb protein. Stokrová, J., Korb, J., Pliss, A., Raska, I., Stulík, J., Dvoráková, M. Int. J. Mol. Med. (2002) [Pubmed]
  4. Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36). Sinclair, P., Harrison, C.J., Jarosová, M., Foroni, L. Haematologica (2005) [Pubmed]
  5. The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Kowenz-Leutz, E., Herr, P., Niss, K., Leutz, A. Cell (1997) [Pubmed]
  6. A myb gene required for leaf trichome differentiation in Arabidopsis is expressed in stipules. Oppenheimer, D.G., Herman, P.L., Sivakumaran, S., Esch, J., Marks, M.D. Cell (1991) [Pubmed]
  7. Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Weston, K., Bishop, J.M. Cell (1989) [Pubmed]
  8. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Klempnauer, K.H., Gonda, T.J., Bishop, J.M. Cell (1982) [Pubmed]
  9. Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. Okada, M., Akimaru, H., Hou, D.X., Takahashi, T., Ishii, S. EMBO J. (2002) [Pubmed]
  10. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. Estus, S., Zaks, W.J., Freeman, R.S., Gruda, M., Bravo, R., Johnson, E.M. J. Cell Biol. (1994) [Pubmed]
  11. Control of plant trichome development by a cotton fiber MYB gene. Wang, S., Wang, J.W., Yu, N., Li, C.H., Luo, B., Gou, J.Y., Wang, L.J., Chen, X.Y. Plant Cell (2004) [Pubmed]
  12. The tomato Blind gene encodes a MYB transcription factor that controls the formation of lateral meristems. Schmitz, G., Tillmann, E., Carriero, F., Fiore, C., Cellini, F., Theres, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  13. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Metcalf, D., Carpinelli, M.R., Hyland, C., Mifsud, S., Dirago, L., Nicola, N.A., Hilton, D.J., Alexander, W.S. Blood (2005) [Pubmed]
  14. Structural organization and expression of human DNA sequences related to the transforming gene of avian myeloblastosis virus. Franchini, G., Wong-Staal, F., Baluda, M.A., Lengel, C., Tronick, S.R. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  15. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Carpinelli, M.R., Hilton, D.J., Metcalf, D., Antonchuk, J.L., Hyland, C.D., Mifsud, S.L., Di Rago, L., Hilton, A.A., Willson, T.A., Roberts, A.W., Ramsay, R.G., Nicola, N.A., Alexander, W.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. A novel class of MYB factors controls sperm-cell formation in plants. Rotman, N., Durbarry, A., Wardle, A., Yang, W.C., Chaboud, A., Faure, J.E., Berger, F., Twell, D. Curr. Biol. (2005) [Pubmed]
  17. Cooperation between the H-ras oncogene and a truncated derivative of the v-myb oncogene in transformation of hamster embryo fibroblasts. Merzak, A., Dooghe, Y., Pironin, M., Perbal, B., Vigier, P. Oncogene (1992) [Pubmed]
  18. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. Jin, H., Cominelli, E., Bailey, P., Parr, A., Mehrtens, F., Jones, J., Tonelli, C., Weisshaar, B., Martin, C. EMBO J. (2000) [Pubmed]
  19. Apparent redundancy in myb gene function provides gearing for the control of flavonoid biosynthesis in antirrhinum flowers. Moyano, E., Martínez-Garcia, J.F., Martin, C. Plant Cell (1996) [Pubmed]
  20. Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle. Reilly, C.F., Kindy, M.S., Brown, K.E., Rosenberg, R.D., Sonenshein, G.E. J. Biol. Chem. (1989) [Pubmed]
  21. Determinants of sequence-specific DNA-binding by p48v-myb. Garcia, A., LaMontagne, K., Reavis, D., Stober-Grässer, U., Lipsick, J.S. Oncogene (1991) [Pubmed]
  22. Modulation of myb gene expression in sponges by retinoic acid. Biesalski, H.K., Doepner, G., Tzimas, G., Gamulin, V., Schröder, H.C., Batel, R., Nau, H., Müller, W.E. Oncogene (1992) [Pubmed]
  23. The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are microRNA-regulated genes that redundantly facilitate anther development. Millar, A.A., Gubler, F. Plant Cell (2005) [Pubmed]
  24. Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis. Hirai, H., Ogawa, M., Suzuki, N., Yamamoto, M., Breier, G., Mazda, O., Imanishi, J., Nishikawa, S. Blood (2003) [Pubmed]
  25. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Kurahashi, T., Nomura, T., Kanei-Ishii, C., Shinkai, Y., Ishii, S. Mol. Biol. Cell (2005) [Pubmed]
  26. Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. Kanei-Ishii, C., Nomura, T., Tanikawa, J., Ichikawa-Iwata, E., Ishii, S. J. Biol. Chem. (2004) [Pubmed]
  27. Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells. Gaillard, C., Le Rouzic, E., Créminon, C., Perbal, B. MP, Mol. Pathol. (2002) [Pubmed]
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