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Gene Review

MYB66  -  transcription factor WER

Arabidopsis thaliana

Synonyms: ATMYB66, T9L3.50, T9L3_50, WER, WER1, ...
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High impact information on WER

  • Disruption of a MYB motif conserved in intron 1 of GL1, WEREWOLF, and GaMYB2 genes affected trichome production [1].
  • The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER, GL2, and its own gene in the alternative position (H) to induce the hair fate [2].
  • To directly test the proposed role of WER in this system, we examined its subcellular localization and defined its transcriptional activation properties [3].
  • In the embryonic hypocotyl we show that WER controls GL2 expression [4].
  • Furthermore, an analysis of the WER and GL1 proteins shows that conserved sequences correspond to specific functional domains [5].

Biological context of WER

  • Positional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cells located in a particular position (N) and adoption of the nonhair fate [2].
  • Nevertheless, reciprocal complementation experiments with a series of gene fusions showed that WER and GL1 encode functionally equivalent proteins, and their unique roles in plant development are entirely due to differences in their cis-regulatory sequences [5].
  • We show that WER, GL2 and CPC are expressed and active during the stages of embryogenesis when the pattern of cells in the epidermis of the root-hypocotyl axis forms [4].
  • SCM regulates the expression of the GLABRA2, CAPRICE, WEREWOLF, and ENHANCER OF GLABRA3 transcription factor genes that define the cell fates [6].

Regulatory relationships of WER

  • In addition, we used the glucocorticoid receptor (GR) inducible system to show that CPC transcription is regulated directly by WER [3].

Other interactions of WER

  • Binding between the WER protein and both WBSs (WBSI and WBSII), and the importance of the two WBSs in CPC promoter activity were confirmed in Arabidopsis [3].

Analytical, diagnostic and therapeutic context of WER

  • Furthermore, we show that these bHLH proteins require a functional WER MYB protein for their action, and they physically interact with WER and CPC in the yeast two-hybrid assay [7].


  1. Control of plant trichome development by a cotton fiber MYB gene. Wang, S., Wang, J.W., Yu, N., Li, C.H., Luo, B., Gou, J.Y., Wang, L.J., Chen, X.Y. Plant Cell (2004) [Pubmed]
  2. Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback. Lee, M.M., Schiefelbein, J. Plant Cell (2002) [Pubmed]
  3. The WEREWOLF MYB protein directly regulates CAPRICE transcription during cell fate specification in the Arabidopsis root epidermis. Ryu, K.H., Kang, Y.H., Park, Y.H., Hwang, I., Schiefelbein, J., Lee, M.M. Development (2005) [Pubmed]
  4. Epidermal patterning genes are active during embryogenesis in Arabidopsis. Costa, S., Dolan, L. Development (2003) [Pubmed]
  5. Developmentally distinct MYB genes encode functionally equivalent proteins in Arabidopsis. Lee, M.M., Schiefelbein, J. Development (2001) [Pubmed]
  6. Positional signaling mediated by a receptor-like kinase in Arabidopsis. Kwak, S.H., Shen, R., Schiefelbein, J. Science (2005) [Pubmed]
  7. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Bernhardt, C., Lee, M.M., Gonzalez, A., Zhang, F., Lloyd, A., Schiefelbein, J. Development (2003) [Pubmed]
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