Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Holla, L.I. et al.

Holla, Fassmann, Benes, Halabala, Znojil,

5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis.

OBJECTIVES: Transforming growth factor-beta (TGF-beta) represents a family of polypeptide growth factors, involved in inflammation and regulation of immune responses. The purpose of this study was to determine whether polymorphisms in the TGF-beta 1 gene may confer susceptibility to adult periodontitis. MATERIAL AND METHODS: We studied 90 patients with adult periodontitis together with 108 unrelated subjects. 3 polymorphisms located in the 5'region at positions -988 (C/A), -800 (G/A) and -509 (C/T) and 2 polymorphisms located at codons 10 ( L10P) and 25 (R25P) of exon 1 were investigated by PCR methods. RESULTS: There was no statistically-significant difference in genotype or allele frequency distributions between patients and reference group for the -800G/A, -509C/T, L10P and R25P polymorphisms (p>0.05 in all cases). The -988 A polymorphism was present neither in our patients nor in unrelated subjects. Upon stratification for smoking status no significant differences were found in the TGF-beta 1 genotype or allele frequencies either between adult periodontitis smokers compared to control smokers, or between periodontitis non-smokers and control non-smokers. CONCLUSION: These data indicate that the mentioned polymorphisms of the TGF-beta 1 gene do not influence susceptibility to adult periodontitis. There was no association between any polymorphisms in the TGF-beta 1 gene, severity of periodontitis and the smoking status in our study.[1]

References

5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis. Holla, L.I., Fassmann, A., Benes, P., Halabala, T., Znojil, V. Journal of clinical periodontology. (2002) [Pubmed]

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