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Minagawa, K. et al.

Minagawa, Kouzuki, Yoshimoto, Kawamura, Tani, Iwata, Terui, Nakai, Yagi, Hattori, Fujiwara, Kamigauchi,

Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. I. Isolation, structure elucidation and biological activities.

Two novel compounds, stachyflin and acetylstachyflin, have been isolated by solid-state fermentation of Stachybotrys sp. RF-7260. The structures of both metabolites, determined by detailed NMR analyses and X-ray crystallographic analysis, are novel with a pentacyclic moiety including cis-fused decalin. The absolute stereochemistry of stachyflins was determined by circular dichroism analysis. Stachyflin showed antiviral activity against influenza A virus (H1N1) in vitro with an IC50 value of 0.003 microM. Acetylstachyflin was about 77-fold less active than stachyflin.[1]

References

Stachyflin and acetylstachyflin, novel anti-influenza A virus substances, produced by Stachybotrys sp. RF-7260. I. Isolation, structure elucidation and biological activities. Minagawa, K., Kouzuki, S., Yoshimoto, J., Kawamura, Y., Tani, H., Iwata, T., Terui, Y., Nakai, H., Yagi, S., Hattori, N., Fujiwara, T., Kamigauchi, T. J. Antibiot. (2002) [Pubmed]

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