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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.

Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-kappaB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53-responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF-kappaB activity, expression of DRAL results in enhancement of NF-kappaB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor.[1]


  1. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. Stilo, R., Leonardi, A., Formisano, L., Di Jeso, B., Vito, P., Liguoro, D. FEBS Lett. (2002) [Pubmed]
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