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Gene Review

CARD8  -  caspase recruitment domain family, member 8

Homo sapiens

Synonyms: Apoptotic protein NDPP1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, Caspase recruitment domain-containing protein 8, DACAR, ...
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Disease relevance of CARD8


Psychiatry related information on CARD8

  • Concurrent measures of relatives and patients including EE, relative distress and patient psychopathology indicated that the Relatives' Cardinal Needs Schedule shows acceptable validity when used with a sample of 45 relatives [6].
  • The Learning Disability version of the Cardinal Needs Schedule (LDCNS) was tested on a sample of 35 people with LD and mental illness for its inter-rater reliability [7].
  • OBJECTIVE: This paper summarizes the development and psychometric evaluation of a new instrument, the Gastroparesis Cardinal Symptom Index (GCSI), for assessing severity of symptoms associated with gastroparesis [8].
  • Staff succeeded despite some seemingly impossible contradictions: John Cardinal O'Connor of the Archdiocese of New York, who has been opposed to the life-styles of most of the people who would use the unit (gays and IV abusers) urged the creation of the unit; St [9].

High impact information on CARD8


Chemical compound and disease context of CARD8

  • The NMS has also been reported in patients with Parkinson's disease after withdrawal of antiparkinsonian agents during "drug holidays." Cardinal features include fever, muscular rigidity, an elevated serum level of creatine phosphokinase, changes in mental status, and autonomic dysfunction [12].

Biological context of CARD8

  • Other anti-apoptotic CARD proteins, such as TUCAN/CARDINAL/CARD8, have been shown to protect tumors from cell death stimuli and to be over-expressed in certain forms of cancer [13].
  • 3. The NDPP1 gene consists of 14 exons and transcribts for at least five splicing variants [14].
  • Nonlinear kinetics were noted for propafenone and NDPP but not for 5-OHP [15].
  • SETTING: Tissue submitted from patients seen at Saint Louis University Department of Dermatology and Cardinal Glennon Children's Hospital in St Louis, Mo, between January 1, 1997, and October 31, 1999 [16].
  • A new electronic aggregometer has been described which measures platelet aggregation by monitoring the changes in electrical impedance that occur when a platelet aggregate forms between two electrodes (Cardinal and Flower, 1980) [17].

Anatomical context of CARD8


Associations of CARD8 with chemical compounds

  • The mean (+/- SD) steady-state concentrations of propafenone, 5-OHP, and NDPP were 1010 +/- 411, 174 +/- 113, and 179 +/- 93 ng/ml [20].
  • Propafenone, a class IC antiarrhythmic agent, is metabolized into two active metabolites: 5-hydroxypropafenone (5-OHP) and N-depropylpropafenone (NDPP) [15].
  • However, the inhibitory protein TUCAN does not play a role in inhibition of procaspase-9 and in determining the sensitivity to cisplatin in NSCLC [1].
  • The medicaments most commonly mistaken for semen were A&D ointment (Cardinal Health, Inc, Dublin, OH), Surgilube (Division of Atlanta, Inc, Melville, NY), Barrier cream (Carrington Laboratories, Inc, Irving, TX), and bacitracin (Division of Atlanta, Inc, Melville, NY) [21].

Other interactions of CARD8


Analytical, diagnostic and therapeutic context of CARD8


  1. TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells. Checinska, A., Giaccone, G., Hoogeland, B.S., Ferreira, C.G., Rodriguez, J.A., Kruyt, F.A. BMC Cancer (2006) [Pubmed]
  2. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. Pathan, N., Marusawa, H., Krajewska, M., Matsuzawa, S., Kim, H., Okada, K., Torii, S., Kitada, S., Krajewski, S., Welsh, K., Pio, F., Godzik, A., Reed, J.C. J. Biol. Chem. (2001) [Pubmed]
  3. TUCAN (CARD8) Genetic Variants and Inflammatory Bowel Disease. McGovern, D.P., Butler, H., Ahmad, T., Paolucci, M., van Heel, D.A., Negoro, K., Hysi, P., Ragoussis, J., Travis, S.P., Cardon, L.R., Jewell, D.P. Gastroenterology (2006) [Pubmed]
  4. A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. Yamamoto, M., Torigoe, T., Kamiguchi, K., Hirohashi, Y., Nakanishi, K., Nabeta, C., Asanuma, H., Tsuruma, T., Sato, T., Hata, F., Ohmura, T., Yamaguchi, K., Kurotaki, T., Hirata, K., Sato, N. Cancer Res. (2005) [Pubmed]
  5. Development and validation of a patient-assessed gastroparesis symptom severity measure: the Gastroparesis Cardinal Symptom Index. Revicki, D.A., Rentz, A.M., Dubois, D., Kahrilas, P., Stanghellini, V., Talley, N.J., Tack, J. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  6. Assessing relatives' needs for psychosocial interventions in schizophrenia: a relatives' version of the Cardinal Needs Schedule (RCNS). Barrowclough, C., Marshall, M., Lockwood, A., Quinn, J., Sellwood, W. Psychological medicine. (1998) [Pubmed]
  7. Assessing the needs of people with learning disabilities and mental illness: development of the Learning Disability version of the Cardinal Needs Schedule. Raghavan, R., Marshall, M., Lockwood, A., Duggan, L. Journal of intellectual disability research : JIDR. (2004) [Pubmed]
  8. Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms. Revicki, D.A., Rentz, A.M., Dubois, D., Kahrilas, P., Stanghellini, V., Talley, N.J., Tack, J. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2004) [Pubmed]
  9. Establishing a dedicated AIDS unit. McGuirk, K., Miles, T. The Journal of nursing administration. (1987) [Pubmed]
  10. Weight control and exercise. Cardinal features of successful preventive gerontology. Hazzard, W.R. JAMA (1995) [Pubmed]
  11. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. Razmara, M., Srinivasula, S.M., Wang, L., Poyet, J.L., Geddes, B.J., DiStefano, P.S., Bertin, J., Alnemri, E.S. J. Biol. Chem. (2002) [Pubmed]
  12. Neuroleptic malignant syndrome: guidelines for treatment and reinstitution of neuroleptics. Olmsted, T.R. South. Med. J. (1988) [Pubmed]
  13. CARD proteins as therapeutic targets in cancer. Damiano, J.S., Reed, J.C. Current drug targets. (2004) [Pubmed]
  14. NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation. Zhang, H., Fu, W. Int. J. Oncol. (2002) [Pubmed]
  15. Pharmacokinetic and pharmacodynamic evaluation of propafenone in patients with ventricular arrhythmia. Propafenone Research Group. Zoble, R.G., Kirsten, E.B., Brewington, J. Clin. Pharmacol. Ther. (1989) [Pubmed]
  16. Infantile hemangiomas: speculation on placental trophoblastic origin. Bree, A.F., Siegfried, E., Sotelo-Avila, C., Nahass, G. Archives of dermatology. (2001) [Pubmed]
  17. Quantitation of platelet mass during aggregation in the electronic (Wellcome) whole blood aggregometer. Challen, A., Branch, W.J., Cummings, J.H. Journal of pharmacological methods. (1982) [Pubmed]
  18. The relative potency of major metabolites and enantiomers of propafenone in an experimental reperfusion arrhythmia model. Oti-Amoako, K., Vozeh, S., Ha, H.R., Follath, F. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  19. Hallux valgus correction by the method of Bösch: a clinical evaluation. Portaluri, M. Foot and ankle clinics. (2000) [Pubmed]
  20. Metabolite cumulation during chronic propafenone dosing in arrhythmia. Kates, R.E., Yee, Y.G., Winkle, R.A. Clin. Pharmacol. Ther. (1985) [Pubmed]
  21. Wood's lamp utility in the identification of semen. Santucci, K.A., Nelson, D.G., McQuillen, K.K., Duffy, S.J., Linakis, J.G. Pediatrics (1999) [Pubmed]
  22. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. Stilo, R., Leonardi, A., Formisano, L., Di Jeso, B., Vito, P., Liguoro, D. FEBS Lett. (2002) [Pubmed]
  23. Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers. Krajewska, M., Kim, H., Kim, C., Kang, H., Welsh, K., Matsuzawa, S., Tsukamoto, M., Thomas, R.G., Assa-Munt, N., Piao, Z., Suzuki, K., Perucho, M., Krajewski, S., Reed, J.C. Clin. Cancer Res. (2005) [Pubmed]
  24. Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment. Rizos, M., Spyropoulos, M.N. European journal of orthodontics. (2004) [Pubmed]
  25. Blunt intestinal injury in children. Diagnostic and therapeutic considerations. Kurkchubasche, A.G., Fendya, D.G., Tracy, T.F., Silen, M.L., Weber, T.R. Archives of surgery (Chicago, Ill. : 1960) (1997) [Pubmed]
  26. The expression of TUCAN, an inhibitor of apoptosis protein, in patients with advanced non-small cell lung cancer treated with chemotherapy. Checinska, A., Oudejans, J.J., Span, S.W., Rodriguez, J.A., Kruyt, F.A., Giaccone, G. Anticancer Res. (2006) [Pubmed]
  27. Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse. Lang, J.H., Zhu, L., Sun, Z.J., Chen, J. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (2003) [Pubmed]
  28. Effects of the program-management model: a case study on professional rehabilitation nursing. Miller, M.A., Miller, L.D. Nursing administration quarterly. (1997) [Pubmed]
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