Disease relevance of CARD8

• TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells [1].
• High levels of endogenous TUCAN protein were detected in several tumor cell lines and in colon cancer specimens, correlating with shorter patient survival [2].
• Methods: Ten single nucleotide polymorphisms (SNP) across TUCAN were genotyped in 365 controls, 372 patients with CD, and 373 patients with ulcerative colitis [3].
• The new variant of TUCAN, termed TUCAN-54, was expressed in gastric, colon, and breast cancer tissues but was barely detected in normal noncancerous tissues, whereas 48-kDa TUCAN was detected in tumor tissues and noncancerous tissues [4].
• Development and validation of a patient-assessed gastroparesis symptom severity measure: the Gastroparesis Cardinal Symptom Index [5].

Psychiatry related information on CARD8

• Concurrent measures of relatives and patients including EE, relative distress and patient psychopathology indicated that the Relatives' Cardinal Needs Schedule shows acceptable validity when used with a sample of 45 relatives [6].
• The Learning Disability version of the Cardinal Needs Schedule (LDCNS) was tested on a sample of 35 people with LD and mental illness for its inter-rater reliability [7].
• OBJECTIVE: This paper summarizes the development and psychometric evaluation of a new instrument, the Gastroparesis Cardinal Symptom Index (GCSI), for assessing severity of symptoms associated with gastroparesis [8].
• Staff succeeded despite some seemingly impossible contradictions: John Cardinal O'Connor of the Archdiocese of New York, who has been opposed to the life-styles of most of the people who would use the unit (gays and IV abusers) urged the creation of the unit; St [9].

High impact information on CARD8

• Weight control and exercise. Cardinal features of successful preventive gerontology [10].
• TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q [3].
• A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis [4].
• One of the CARD-containing proteins, TUCAN (CARD8), was reported previously as an antiapoptotic protein with a molecular weight of 48 kDa, which was up-regulated in colon cancer cells [4].
• CARD-8 was also found to negatively regulate NF-kappaB activation by TNF-alpha stimulation and by ectopically expressed RICK, suggesting that this protein may control cell survival [11].

Chemical compound and disease context of CARD8

• The NMS has also been reported in patients with Parkinson's disease after withdrawal of antiparkinsonian agents during "drug holidays." Cardinal features include fever, muscular rigidity, an elevated serum level of creatine phosphokinase, changes in mental status, and autonomic dysfunction [12].

Biological context of CARD8

• Other anti-apoptotic CARD proteins, such as TUCAN/CARDINAL/CARD8, have been shown to protect tumors from cell death stimuli and to be over-expressed in certain forms of cancer [13].
• 3. The NDPP1 gene consists of 14 exons and transcribts for at least five splicing variants [14].
• Nonlinear kinetics were noted for propafenone and NDPP but not for 5-OHP [15].
• SETTING: Tissue submitted from patients seen at Saint Louis University Department of Dermatology and Cardinal Glennon Children's Hospital in St Louis, Mo, between January 1, 1997, and October 31, 1999 [16].
• A new electronic aggregometer has been described which measures platelet aggregation by monitoring the changes in electrical impedance that occur when a platelet aggregate forms between two electrodes (Cardinal and Flower, 1980) [17].

Anatomical context of CARD8

• We demonstrate that CARD-8 interacts physically with caspase-1 and negatively regulates caspase-1-dependent IL-1beta generation in the THP-1 monocytic cell line [11].
• Reverse transcriptase-PCR analysis revealed that CARD-8 is expressed mainly in monocytes, placenta, lymph nodes, and spleen [11].
• The mRNA expression of NDPP1 was higher in the kidney and testis of normal tissues [14].
• We used isolated rat hearts subjected to coronary artery ligation and reperfusion to study the antiarrhythmic activity of 5-hydroxypropafenone (5OHP) and N-depropylpropafenone (NDPP), major metabolites of propafenone (P) in humans, and of the two enantiomers (R)- and (S)-propafenone [18].
• Between December 1996 and February 1999, 197 operations for the correction of hallux valgus by the percutaneous technique of Bösch were performed in 156 patients (41 bilateral) at the Cardinal G [19].

Associations of CARD8 with chemical compounds

• The mean (+/- SD) steady-state concentrations of propafenone, 5-OHP, and NDPP were 1010 +/- 411, 174 +/- 113, and 179 +/- 93 ng/ml [20].
• Propafenone, a class IC antiarrhythmic agent, is metabolized into two active metabolites: 5-hydroxypropafenone (5-OHP) and N-depropylpropafenone (NDPP) [15].
• However, the inhibitory protein TUCAN does not play a role in inhibition of procaspase-9 and in determining the sensitivity to cisplatin in NSCLC [1].
• The medicaments most commonly mistaken for semen were A&D ointment (Cardinal Health, Inc, Dublin, OH), Surgilube (Division of Atlanta, Inc, Melville, NY), Barrier cream (Carrington Laboratories, Inc, Irving, TX), and bacitracin (Division of Atlanta, Inc, Melville, NY) [21].

Other interactions of CARD8

• TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation [22].
• RESULTS: Elevated expression of several apoptosis regulators significantly correlated with either shorter (cIAP2; TUCAN) or longer (Apaf1; Bcl-2) overall survival in univariate and multivariate analyses [23].
• Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment [24].

Analytical, diagnostic and therapeutic context of CARD8

• For 19 of the 22 patients, the initial physical examination was conducted at Cardinal Glennon Children's Hospital, St Louis, Mo, and 18 of the 19 patients underwent a concurrent CT evaluation [25].
• There was no significant correlation between the localization of TUCAN and response to chemotherapy [26].
• METHODS: Cardinal ligament and uterosacral ligament samples were obtained from 73 women undergoing hysterectomy [27].
• In an attempt to increase organizational innovation and flexibility, Cardinal Hill Rehabilitation Hospital moved from the traditional discipline-management model to the program-management model [28].

References