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Gene Review

PRG1  -  p53-responsive gene 1

Homo sapiens

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Disease relevance of PRG1


High impact information on PRG1


Biological context of PRG1


Anatomical context of PRG1


Associations of PRG1 with chemical compounds


Physical interactions of PRG1


Regulatory relationships of PRG1


Other interactions of PRG1

  • Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells [35].
  • Additionally, we demonstrate that the translational enhancement of mdm2 involves a preferential increase in mdm2 transcription that is initiated from the internal p53-responsive promoter region of this gene [36].
  • It has been recently hypothesized that the CD59 gene has two putative p53-responsive elements that may be involved in defense of host cells from damage by the complement system in inflammation [37].
  • The BRCA1 and p53 tumor suppressors have been shown to interact and cooperate to activate transcription of p53-responsive genes [38].
  • The induction of several p53-responsive genes as well as a small form of p130 (S-p130) was detected upon p53 activation [39].

Analytical, diagnostic and therapeutic context of PRG1


  1. A proliferative p53-responsive element mediates tumor necrosis factor alpha induction of the human immunodeficiency virus type 1 long terminal repeat. Gualberto, A., Hixon, M.L., Finco, T.S., Perkins, N.D., Nabel, G.J., Baldwin, A.S. Mol. Cell. Biol. (1995) [Pubmed]
  2. p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells. Takemoto, S., Trovato, R., Cereseto, A., Nicot, C., Kislyakova, T., Casareto, L., Waldmann, T., Torelli, G., Franchini, G. Blood (2000) [Pubmed]
  3. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. Spurgers, K.B., Gold, D.L., Coombes, K.R., Bohnenstiehl, N.L., Mullins, B., Meyn, R.E., Logothetis, C.J., McDonnell, T.J. J. Biol. Chem. (2006) [Pubmed]
  4. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Wang, W., Huper, G., Guo, Y., Murphy, S.K., Olson, J.A., Marks, J.R. Oncogene (2005) [Pubmed]
  5. deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. King, K.E., Ponnamperuma, R.M., Yamashita, T., Tokino, T., Lee, L.A., Young, M.F., Weinberg, W.C. Oncogene (2003) [Pubmed]
  6. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Moumen, A., Masterson, P., O'Connor, M.J., Jackson, S.P. Cell (2005) [Pubmed]
  7. A polymorphic microsatellite that mediates induction of PIG3 by p53. Contente, A., Dittmer, A., Koch, M.C., Roth, J., Dobbelstein, M. Nat. Genet. (2002) [Pubmed]
  8. Role of the p53-homologue p73 in E2F1-induced apoptosis. Stiewe, T., Pützer, B.M. Nat. Genet. (2000) [Pubmed]
  9. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Jost, C.A., Marin, M.C., Kaelin, W.G. Nature (1997) [Pubmed]
  10. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Yin, C., Knudson, C.M., Korsmeyer, S.J., Van Dyke, T. Nature (1997) [Pubmed]
  11. AMID is a p53-inducible gene downregulated in tumors. Wu, M., Xu, L.G., Su, T., Tian, Y., Zhai, Z., Shu, H.B. Oncogene (2004) [Pubmed]
  12. The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. Schäfer, H., Diebel, J., Arlt, A., Trauzold, A., Schmidt, W.E. FEBS Lett. (1998) [Pubmed]
  13. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Zhao, R., Gish, K., Murphy, M., Yin, Y., Notterman, D., Hoffman, W.H., Tom, E., Mack, D.H., Levine, A.J. Genes Dev. (2000) [Pubmed]
  14. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Hermeking, H., Lengauer, C., Polyak, K., He, T.C., Zhang, L., Thiagalingam, S., Kinzler, K.W., Vogelstein, B. Mol. Cell (1997) [Pubmed]
  15. BID regulation by p53 contributes to chemosensitivity. Sax, J.K., Fei, P., Murphy, M.E., Bernhard, E., Korsmeyer, S.J., El-Deiry, W.S. Nat. Cell Biol. (2002) [Pubmed]
  16. Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I. Aoyama, N., Nagase, T., Sawazaki, T., Mizuguchi, G., Nakagoshi, H., Fujisawa, J.I., Yoshida, M., Ishii, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters. Estève, P.O., Chin, H.G., Pradhan, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  18. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Di Como, C.J., Gaiddon, C., Prives, C. Mol. Cell. Biol. (1999) [Pubmed]
  19. p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Feng, Z., Jin, S., Zupnick, A., Hoh, J., de Stanchina, E., Lowe, S., Prives, C., Levine, A.J. Oncogene (2006) [Pubmed]
  20. NBP is the p53 homolog p63. Zeng, X., Zhu, Y., Lu, H. Carcinogenesis (2001) [Pubmed]
  21. Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Roemer, K., Friedmann, T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Jiang, M., Wei, Q., Wang, J., Du, Q., Yu, J., Zhang, L., Dong, Z. Oncogene (2006) [Pubmed]
  23. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Jeong, S.J., Pise-Masison, C.A., Radonovich, M.F., Park, H.U., Brady, J.N. Oncogene (2005) [Pubmed]
  24. Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain. Roth, J., Koch, P., Contente, A., Dobbelstein, M. Oncogene (2000) [Pubmed]
  25. p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: a novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes. Wu, H.H., Thomas, J.A., Momand, J. Biochem. J. (2000) [Pubmed]
  26. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Lu, H., Fisher, R.P., Bailey, P., Levine, A.J. Mol. Cell. Biol. (1997) [Pubmed]
  27. A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. Arva, N.C., Gopen, T.R., Talbott, K.E., Campbell, L.E., Chicas, A., White, D.E., Bond, G.L., Levine, A.J., Bargonetti, J. J. Biol. Chem. (2005) [Pubmed]
  28. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. Wu, H., Lozano, G. J. Biol. Chem. (1994) [Pubmed]
  29. Insights into selective activation of p53 DNA binding by c-Abl. Wei, G., Li, A.G., Liu, X. J. Biol. Chem. (2005) [Pubmed]
  30. BRCA1 regulates p53-dependent gene expression. Ouchi, T., Monteiro, A.N., August, A., Aaronson, S.A., Hanafusa, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  31. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. Wong, K., Zhang, J., Awasthi, S., Sharma, A., Rogers, L., Matlock, E.F., Van Lint, C., Karpova, T., McNally, J., Harrod, R. J. Biol. Chem. (2004) [Pubmed]
  32. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Wei, X., Xu, H., Kufe, D. Cancer Cell (2005) [Pubmed]
  33. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. Huang, S.M., Schönthal, A.H., Stallcup, M.R. Oncogene (2001) [Pubmed]
  34. Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells. Rallapalli, R., Strachan, G., Tuan, R.S., Hall, D.J. J. Cell. Biochem. (2003) [Pubmed]
  35. Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells. Schäfer, H., Lettau, P., Trauzold, A., Banasch, M., Schmidt, W.E. Pancreas (1999) [Pubmed]
  36. Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. Landers, J.E., Cassel, S.L., George, D.L. Cancer Res. (1997) [Pubmed]
  37. p53 regulates cellular resistance to complement lysis through enhanced expression of CD59. Donev, R.M., Cole, D.S., Sivasankar, B., Hughes, T.R., Morgan, B.P. Cancer Res. (2006) [Pubmed]
  38. Repression of BRCA1 through a feedback loop involving p53. MacLachlan, T.K., Dash, B.C., Dicker, D.T., El-Deiry, W.S. J. Biol. Chem. (2000) [Pubmed]
  39. P130 and its truncated form mediate p53-induced cell cycle arrest in Rb(-/-) Saos2 cells. Gao, C.F., Ren, S., Wang, J., Zhang, S.L., Jin, F., Nakajima, T., Ikeda, M., Tsuchida, N. Oncogene (2002) [Pubmed]
  40. p22/PACAP response gene 1 (PRG1): a putative target gene for the tumor suppressor p53. Schäfer, H., Trauzold, A., Sebens, T., Deppert, W., Fölsch, U.R., Schmidt, W.E. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  41. 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Kondo, M., Shibata, T., Kumagai, T., Osawa, T., Shibata, N., Kobayashi, M., Sasaki, S., Iwata, M., Noguchi, N., Uchida, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  42. Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level. Karlsson, G.B., Jensen, A., Stevenson, L.F., Woods, Y.L., Lane, D.P., Sørensen, M.S. Br. J. Cancer (2004) [Pubmed]
  43. Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses. Satoh, J., Tabunoki, H., Nanri, Y., Arima, K., Yamamura, T. Neurosci. Res. (2006) [Pubmed]
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