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Neophytides, A.N. et al.

Sodium valproate in the treatment of cerebellar disorders.

Because of the high concentrations of gamma-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.[1]

References

Sodium valproate in the treatment of cerebellar disorders. Neophytides, A.N., Teychenne, P.F., Pfeiffer, R.F., Calne, D.B. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1979) [Pubmed]

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