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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats.

The effects of thymosin alpha1 (Talpha1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats. Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. Animals treated with exogenous Talpha1 had a significantly greater blood white cell density than control Fisher rats. These results suggest that Talpha1 prevents mammary carcinoma incidence as a result of stimulation of the immune system.[1]


  1. Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats. Moody, T.W., Tuthill, C., Badamchian, M., Goldstein, A.L. Peptides (2002) [Pubmed]
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