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Chemical Compound Review

NSC-23909     1-methyl-1-nitroso-urea

Synonyms: CCRIS 404, CHEMBL288958, AG-E-60227, AG-L-66288, NMH [German], ...
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  1. Activation of ras oncogenes preceding the onset of neoplasia. Kumar, R., Sukumar, S., Barbacid, M. Science (1990) [Pubmed]
  2. The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Dumenco, L.L., Allay, E., Norton, K., Gerson, S.L. Science (1993) [Pubmed]
  3. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Sporn, M.B., Squire, R.A., Brown, C.C., Smith, J.M., Wenk, M.L., Springer, S. Science (1977) [Pubmed]
  4. Circadian variation in the induction of intestinal tumors by N-methyl-N-nitrosourea in male C57BL/6N mice. Beland, F.A., Dooley, K.L., Sheldon, W.G., Delongchamp, R.R. J. Natl. Cancer Inst. (1988) [Pubmed]
  5. Thy-1 antigen on normal and neoplastic rat mammary tissues: changes in location and amount of antigen during differentiation of cultured stem cells. Rudland, P.S., Warburton, M.J., Monaghan, P., Ritter, M.A. J. Natl. Cancer Inst. (1982) [Pubmed]
  6. N-methyl-N-nitrosourea-induced rat mammary tumors. Hormone responsiveness but lack of spontaneous metastasis. Williams, J.C., Gusterson, B., Humphreys, J., Monaghan, P., Coombes, R.C., Rudland, P., Neville, A.M. J. Natl. Cancer Inst. (1981) [Pubmed]
  7. Impaired Biel and radial arm maze learning in rats with methylnitrosourea-induced microcephaly. Akaike, M., Tanaka, K., Goto, M., Sakaguchi, T. Neurotoxicology and teratology. (1988) [Pubmed]
  8. DNA-repair capacity and lipid peroxidation in chronic alcoholics. Topinka, J., Binková, B., Srám, R.J., Fojtíková, I. Mutat. Res. (1991) [Pubmed]
  9. Comutagenic effects exerted by N-nitroso compounds. Guttenplan, J.B. Mutat. Res. (1979) [Pubmed]
  10. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Branch, P., Aquilina, G., Bignami, M., Karran, P. Nature (1993) [Pubmed]
  11. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D., Barbacid, M. Nature (1985) [Pubmed]
  12. DNA precursors in chemical mutagenesis: a novel application of DNA sequencing. Topal, M.D., Hutchison, C.A., Baker, M.S. Nature (1982) [Pubmed]
  13. Genotoxicity of formaldehyde in cultured human bronchial fibroblasts. Grafstrom, R.C., Curren, R.D., Yang, L.L., Harris, C.C. Science (1985) [Pubmed]
  14. Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. Angel, J.M., Morizot, D.C., Richie, E.R. J. Natl. Cancer Inst. (1989) [Pubmed]
  15. Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response. Frei, J.V., Lawley, P.D. J. Natl. Cancer Inst. (1980) [Pubmed]
  16. Effects of bile acids on carcinogen-exposed rat colon in organ culture and as subsequent long-term transplants. Reiss, B., Weiss, C.J., Tanaka, T., Reddy, B., Williams, G.M. J. Natl. Cancer Inst. (1987) [Pubmed]
  17. Production of autochthonous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone. Pollard, M., Luckert, P.H. J. Natl. Cancer Inst. (1986) [Pubmed]
  18. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Yamamoto, S., Konishi, Y., Matsuda, T., Murai, T., Shibata, M.A., Matsui-Yuasa, I., Otani, S., Kuroda, K., Endo, G., Fukushima, S. Cancer Res. (1995) [Pubmed]
  19. Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors and cell kinetics in rats. Cohen, B.I., Raicht, R.F., Deschner, E.E., Takahashi, M., Sarwal, A.N., Fazzini, E. J. Natl. Cancer Inst. (1980) [Pubmed]
  20. N-nitroso-N-methylurea-induced mammary carcinogenesis: effect of pregnancy on preneoplastic cells. Grubbs, C.J., Hill, D.L., McDonough, K.C., Peckham, J.C. J. Natl. Cancer Inst. (1983) [Pubmed]
  21. N-Methyl-N-nitrosourea and saccharin: effects on epithelium of normal human urinary bladder in vitro. El-Gerzawi, S., Heatfield, B.M., Trump, B.F. J. Natl. Cancer Inst. (1982) [Pubmed]
  22. DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Richardson, K.K., Richardson, F.C., Crosby, R.M., Swenberg, J.A., Skopek, T.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  23. Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid. Dixit, R., Gold, B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Effects of isoproterenol on mammary gland tumors induced by N-nitroso-N-methylurea and salivary gland tumors induced by 7,12-dimethylbenz[a]anthracene. Barka, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  25. Primary culture of rat mammary epithelial cells. II. Cytotoxic effect and metabolism of 7,12-dimethylbenz[a]anthracene and N-nitroso-N-methylurea. Richards, J., Nandi, S. J. Natl. Cancer Inst. (1978) [Pubmed]
  26. Induction of unscheduled DNA synthesis in rat stomach mucosa by glandular stomach carcinogens. Furihata, C., Yamawaki, Y., Jin, S.S., Moriya, H., Kodama, K., Matsushima, T., Ishikawa, T., Takayama, S., Nakadate, M. J. Natl. Cancer Inst. (1984) [Pubmed]
  27. Promotion of N-methyl-N-nitrosourea-induced thyroid tumors by iodine deficiency in F344/NCr rats. Ohshima, M., Ward, J.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  28. Histogenesis and dose dependence of N-methyl-N-nitrosourea-induced carcinoma in a localized area of the hamster trachea. Becci, P.J., Thompson, H.J., Grubbs, C.J., Moon, R.C. J. Natl. Cancer Inst. (1980) [Pubmed]
  29. Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea. Grubbs, C.J., Becci, P.J., Thompson, H.J., Moon, R.C. J. Natl. Cancer Inst. (1981) [Pubmed]
  30. Effect of duration of high fat intake on enhancement of mammary carcinogenesis in rats. Dao, T.L., Chan, P.C. J. Natl. Cancer Inst. (1983) [Pubmed]
  31. Induction of lung cancers in preselected, localized sites in the dog. Paladugu, R.R., Shors, E.C., Cohen, A.H., Matsumura, K., Benfield, J.R. J. Natl. Cancer Inst. (1980) [Pubmed]
  32. Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea. González-Suárez, E., Goytisolo, F.A., Flores, J.M., Blasco, M.A. Cancer Res. (2003) [Pubmed]
  33. Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. Christmann, M., Kaina, B. J. Biol. Chem. (2000) [Pubmed]
  34. Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. Guo, W.H., Weng, L.Q., Ito, K., Chen, L.F., Nakanishi, H., Tatematsu, M., Ito, Y. Oncogene (2002) [Pubmed]
  35. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents. Humbert, O., Fiumicino, S., Aquilina, G., Branch, P., Oda, S., Zijno, A., Karran, P., Bignami, M. Carcinogenesis (1999) [Pubmed]
  36. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Sgambato, A., Han, E.K., Zhang, Y.J., Moon, R.C., Santella, R.M., Weinstein, I.B. Carcinogenesis (1995) [Pubmed]
  37. Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea. Konstantinidis, A., Smulow, J.B., Sonnenschein, C. Science (1982) [Pubmed]
  38. Prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats by 1alpha-hydroxyvitamin D(5). Mehta, R., Hawthorne, M., Uselding, L., Albinescu, D., Moriarty, R., Christov, K., Mehta, R. J. Natl. Cancer Inst. (2000) [Pubmed]
  39. Response to ovariectomy of N-methyl-N-nitrosourea-induced mammary tumors in the rat. Turcot-Lemay, L., Kelly, P.A. J. Natl. Cancer Inst. (1981) [Pubmed]
  40. Effect of BCG immunotherapy on N-nitroso-N-methylurea-induced carcinogenesis of guinea pig colon. Cockerell, G.L., O'Donnell, R.W., Kriedemann, W.L., Amato, D.A., Turnbull, B.W. J. Natl. Cancer Inst. (1984) [Pubmed]
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