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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Novel diterpene lactones from Suregada multiflora.

Two new diterpene lactones, suregadolides A (1) and B (2), were isolated from a dichloromethane extract of Suregada multiflora bark. These compounds possess a novel skeleton, which contains a cyclopropane ring bridging C-3 and C-4 of the abietane skeleton. The structures were established on the basis of one- and two-dimensional NMR and other spectroscopic studies. Compound 1 showed moderate inhibitory activity in a mutant yeast strain bioassay.[1]


  1. Novel diterpene lactones from Suregada multiflora. Jahan, I.A., Nahar, N., Mosihuzzaman, M., Shaheen, F., Parween, Z., Atta-ur-Rahman, n.u.l.l., Choudhary, M.I. J. Nat. Prod. (2002) [Pubmed]
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