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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Does direct measurement of forearm mixed nerve conduction velocity reflect actual nerve conduction velocity through the carpal tunnel?

OBJECTIVES: The purpose of this study was to determine whether forearm (wrist-elbow) mixed nerve conduction velocity (W-Emix) represents the actual nerve conduction velocity (CV) of nerve fibers passing through the carpal tunnel. BACKGROUND: W-Emix is presumed to reflect the actual forearm CV through the carpal tunnel. However, it has been argued that W-Emix chiefly originates from the nerve fibers passing outside the carpal tunnel. Therefore, the direct measurement of W-Emix cannot be used to assess retrograde axonal atrophy in carpal tunnel syndrome ( CTS). SUBJECTS AND METHODS: Thirty patients with clinical signs and symptoms of CTS were recruited and the diagnosis was confirmed with standard electrodiagnosis. Fifty age-matched volunteers served as control. Recording electrodes were placed over the elbow and index finger for mixed nerve and sensory nerve conduction studies, respectively. Stimulation was applied at the palm and wrist for the measurement of mixed nerve wrist-palm CV (W-Pmix), wrist-elbow CV (W-Emix), and elbow-palm CV (E-Pmix). Stimulation was applied at the elbow, wrist, and palm for the measurement of wrist-elbow sensory CV (W-Esen), wrist-palm CV (W-Psen), and elbow-palm CV (E-Psen). Comparisons were made between W-Pmix and W-Psen, W-Emix and W-Esen, and E-Pmix and E-Psen. RESULTS: Correlations between W-Emix and W-Esen, E-Pmix and E-Psen, and W-Pmix and W-Psen were good in the control. In the patient group, there was a strong positive correlation between W-Pmix and W-Psen, and between E-Pmix and E-Psen. However, W-Esen correlated weakly with W-Emix, suggesting that W-Emix chiefly represents the CV of fibers passing outside the carpal tunnel. Therefore, the direct measurement of W-Emix cannot be used to assess retrograde axonal atrophy. Furthermore, the reduction in W-Psen was more marked than the reduction in W-Esen, implying that a conduction block at the wrist is the least likely cause of proximal slowing in CTS. CONCLUSIONS: W-Emix does not reflect the actual CV of the nerve fibers passing through the carpal tunnel. In addition, retrograde axonal atrophy appears to be the primary cause of decreased forearm CV in CTS.[1]

References

  1. Does direct measurement of forearm mixed nerve conduction velocity reflect actual nerve conduction velocity through the carpal tunnel? Chang, M.H., Wei, S.J., Chiang, H.L., Wang, H.M., Hsieh, P.F., Huang, S.Y. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2002) [Pubmed]
 
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