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Gene Review

CTS1  -  carpal tunnel syndrome 1

Homo sapiens

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Disease relevance of CTS1

  • Electron microscopic analysis of Ad-CTS1-infected glioma cells reveals complex cytoplasmic pathology and delayed apoptotic changes [1].
  • In this study, the antitumoral activity of CTS1 mediated by adenovirus vector has been evaluated in comparison with a p53 adenovirus vector in various human tumor cell lines [2].
  • CONCLUSION: In this preliminary study, a yoga-based regimen was more effective than wrist splinting or no treatment in relieving some symptoms and signs of carpal tunnel syndrome [3].
  • Several traditional findings of CTS have little or no diagnostic value, including nocturnal paresthesias; Phalen and Tinel signs; thenar atrophy; and 2-point, vibratory, and monofilament sensory testing [4].
  • Among these 6 women, symptoms included transient arthritis or arthralgias (<6 weeks duration) in 4 women, arthralgia of indeterminate chronicity in 1 woman, and carpal tunnel syndrome in 1 woman [5].

Psychiatry related information on CTS1


High impact information on CTS1


Chemical compound and disease context of CTS1


Biological context of CTS1


Anatomical context of CTS1


Associations of CTS1 with chemical compounds


Regulatory relationships of CTS1


Other interactions of CTS1


Analytical, diagnostic and therapeutic context of CTS1


  1. Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand. Naumann, U., Kügler, S., Wolburg, H., Wick, W., Rascher, G., Schulz, J.B., Conseiller, E., Bähr, M., Weller, M. Cancer Res. (2001) [Pubmed]
  2. Cancer gene therapy mediated by CTS1, a p53 derivative: advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2. Bougeret, C., Virone-Oddos, A., Adeline, E., Lacroix, F., Lefranc, C., Ferrero, L., Huet, T. Cancer Gene Ther. (2000) [Pubmed]
  3. Yoga-based intervention for carpal tunnel syndrome: a randomized trial. Garfinkel, M.S., Singhal, A., Katz, W.A., Allan, D.A., Reshetar, R., Schumacher, H.R. JAMA (1998) [Pubmed]
  4. The rational clinical examination. Does this patient have carpal tunnel syndrome? D'Arcy, C.A., McGee, S. JAMA (2000) [Pubmed]
  5. Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. Ray, P., Black, S., Shinefield, H., Dillon, A., Schwalbe, J., Holmes, S., Hadler, S., Chen, R., Cochi, S., Wassilak, S. JAMA (1997) [Pubmed]
  6. The neuromythology of silicone breast implants. Rosenberg, N.L. Neurology (1996) [Pubmed]
  7. Trichotillomania and carpal tunnel syndrome. O'Sullivan, R.L., Keuthen, N.J., Jenike, M.A., Gumley, G. The Journal of clinical psychiatry. (1996) [Pubmed]
  8. Occupational disability after hospitalization for the treatment of an injury of the anterior cruciate ligament. Dunn, W.R., Lincoln, A.E., Hinton, R.Y., Smith, G.S., Amoroso, P.J. The Journal of bone and joint surgery. American volume. (2003) [Pubmed]
  9. Carpal tunnel syndrome: staging of median nerve compression by MR imaging. Kleindienst, A., Hamm, B., Lanksch, W.R. Journal of magnetic resonance imaging : JMRI. (1998) [Pubmed]
  10. Illness behavior and psychosocial factors in diffuse upper limb pain disorder: a case-control study. White, P.D., Henderson, M., Pearson, R.M., Coldrick, A.R., White, A.G., Kidd, B.L. J. Rheumatol. (2003) [Pubmed]
  11. Prevalence of carpal tunnel syndrome in a general population. Atroshi, I., Gummesson, C., Johnsson, R., Ornstein, E., Ranstam, J., Rosén, I. JAMA (1999) [Pubmed]
  12. Bromocriptine for an acromegalic patient. Improvement in cardiac function and carpal tunnel syndrome. Luboshitzky, R., Barzilai, D. JAMA (1980) [Pubmed]
  13. Carpal tunnel syndrome. Importance of sensory nerve conduction studies in diagnosis. Hoffman, D.E. JAMA (1975) [Pubmed]
  14. Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. Ellis, J.M., Folkers, K., Levy, M., Shizukuishi, S., Lewandowski, J., Nishii, S., Schubert, H.A., Ulrich, R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  15. Synovial amyloidosis in patients undergoing long-term hemodialysis. Bardin, T., Kuntz, D., Zingraff, J., Voisin, M.C., Zelmar, A., Lansaman, J. Arthritis Rheum. (1985) [Pubmed]
  16. Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70. Izumoto, S., Younger, D., Hays, A.P., Martone, R.L., Smith, R.T., Herbert, J. Neurology (1992) [Pubmed]
  17. Lithium-induced carpal tunnel syndrome. Deahl, M.P. The British journal of psychiatry : the journal of mental science. (1988) [Pubmed]
  18. A deficiency of vitamin B6 is a plausible molecular basis of the retinopathy of patients with diabetes mellitus. Ellis, J.M., Folkers, K., Minadeo, M., VanBuskirk, R., Xia, L.J., Tamagawa, H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  19. CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties. Conseiller, E., Debussche, L., Landais, D., Venot, C., Maratrat, M., Sierra, V., Tocque, B., Bracco, L. J. Clin. Invest. (1998) [Pubmed]
  20. Primary familial bilateral carpal tunnel syndrome. Gray, R.G., Poppo, M.J., Gottlieb, N.L. Ann. Intern. Med. (1979) [Pubmed]
  21. beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis. Miyata, T., Oda, O., Inagi, R., Iida, Y., Araki, N., Yamada, N., Horiuchi, S., Taniguchi, N., Maeda, K., Kinoshita, T. J. Clin. Invest. (1993) [Pubmed]
  22. Efficacy of provocative tests for diagnosis of carpal tunnel syndrome. de Krom, M.C., Knipschild, P.G., Kester, A.D., Spaans, F. Lancet (1990) [Pubmed]
  23. Enzymology of the response of the carpal tunnel syndrome to riboflavin and to combined riboflavin and pyridoxine. Folkers, K., Wolaniuk, A., Vadhanavikit, S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  24. Carpal tunnel syndrome associated with mixed calcium pyrophosphate dihydrate and apatite crystal deposition in tendon synovial sheath. Lagier, R., Boivin, G., Gerster, J.C. Arthritis Rheum. (1984) [Pubmed]
  25. Epidemiologic surveillance of upper-extremity musculoskeletal disorders in the working population. Roquelaure, Y., Ha, C., Leclerc, A., Touranchet, A., Sauteron, M., Melchior, M., Imbernon, E., Goldberg, M. Arthritis Rheum. (2006) [Pubmed]
  26. Pyridoxine in carpal tunnel syndrome. Scheyer, R.D., Haas, D.C. Lancet (1985) [Pubmed]
  27. Biochemical evidence for a deficiency of vitamin B6 in the carpal tunnel syndrome based on a crossover clinical study. Folkers, K., Ellis, J., Watanabe, T., Saji, S., Kaji, M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  28. Surgery versus steroid injection in carpal tunnel syndrome: comment on the article by Ly-Pen et al. Hui, A.C., Wong, S.M. Arthritis Rheum. (2005) [Pubmed]
  29. PCTAIRE3: a putative mediator of growth arrest and death induced by CTS-1, a dominant-positive p53-derived synthetic tumor suppressor, in human malignant glioma cells. Naumann, U., Huang, H., Wolburg, H., Wischhusen, J., Weit, S., Ohgaki, H., Weller, M. Cancer Gene Ther. (2006) [Pubmed]
  30. COX-2 up-regulation in idiopathic carpal tunnel syndrome. Talmor, M., Patel, M.P., Spann, M.D., Barden, C., Specht, M., McLean, A., Harper, A., Hoffman, L.A., Nolan, W.B. Plast. Reconstr. Surg. (2003) [Pubmed]
  31. New mutant gene (transthyretin Arg 58) in cases with hereditary polyneuropathy detected by non-isotope method of single-strand conformation polymorphism analysis. Saeki, Y., Ueno, S., Yorifuji, S., Sugiyama, Y., Ide, Y., Matsuzawa, Y. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  32. Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients. Omori, K., Kazama, J.J., Song, J., Goto, S., Takada, T., Saito, N., Sakatsume, M., Narita, I., Gejyo, F. Amyloid (2002) [Pubmed]
  33. Effect of HLA type and hypocomplementaemia on the expression of parvovirus arthritis: one year follow up of an outbreak. Gendi, N.S., Gibson, K., Wordsworth, B.P. Ann. Rheum. Dis. (1996) [Pubmed]
  34. Carpal tunnel syndrome in patients undergoing maintenance hemodialysis. Jain, V.K., Cestero, R.V., Baum, J. JAMA (1979) [Pubmed]
  35. Yoga for carpal tunnel syndrome. Harrast, M., Kraft, G. JAMA (1999) [Pubmed]
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