Disease relevance of CTS1

• Electron microscopic analysis of Ad-CTS1-infected glioma cells reveals complex cytoplasmic pathology and delayed apoptotic changes [1].
• In this study, the antitumoral activity of CTS1 mediated by adenovirus vector has been evaluated in comparison with a p53 adenovirus vector in various human tumor cell lines [2].
• CONCLUSION: In this preliminary study, a yoga-based regimen was more effective than wrist splinting or no treatment in relieving some symptoms and signs of carpal tunnel syndrome [3].
• Several traditional findings of CTS have little or no diagnostic value, including nocturnal paresthesias; Phalen and Tinel signs; thenar atrophy; and 2-point, vibratory, and monofilament sensory testing [4].
• Among these 6 women, symptoms included transient arthritis or arthralgias (<6 weeks duration) in 4 women, arthralgia of indeterminate chronicity in 1 woman, and carpal tunnel syndrome in 1 woman [5].

Psychiatry related information on CTS1

• Neurologic symptoms could be explained in some cases by depression (n=16), fibromyalgia (n=9), radiculopathy (n=7), anxiety disorders (n=4), multiple sclerosis (n=4), multifocal motor neuropathy (n=1), carpal tunnel syndrome (n=1), dermatomyositis (n=1), and other psychiatric disorders (n=3) [6].
• Trichotillomania and carpal tunnel syndrome [7].
• CONCLUSIONS: In keeping with risk profiles of several other musculoskeletal disorders, such as low-back pain and carpal tunnel syndrome, the results revealed a multifactorial risk profile in which psychosocial factors were strongly associated with disability discharge from active military duty after injury of the anterior cruciate ligament [8].
• Hence, MR imaging allows staging of median nerve compression in CTS and thus may contribute to therapeutic decision-making [9].
• OBJECTIVE: To compare behavioral and other psychosocial factors in patients with diffuse upper limb pain disorder (ULPD) and patients with carpal tunnel syndrome (CTS) [10].

High impact information on CTS1

• MAIN OUTCOME MEASURES: Population prevalence rates, calculated as the number of symptomatic responders diagnosed on examination as having clinically certain CTS and/or electrophysiological median neuropathy divided by the total number of responders [11].
• RESULTS: No significantly increased risk was associated with receipt of rubella vaccine for any outcome except for prevalence of carpal tunnel syndrome in vaccinated women at least 30 years old compared with seropositive, unvaccinated women (2.9% vs 1.4%; P=.03) [5].
• Bromocriptine may correct cardiac dysfunction and carpal tunnel syndrome in acromegaly either by reduction of GH oversecretion or by a direct effect of bromocriptine on dopamine receptors in the heart and peripheral nerve endings [12].
• A 64-year-old woman with active acromegaly of 33 years' duration, severe carpal tunnel syndrome, and subclinical heart disease was treated with bromocriptine mesylate [12].
• Carpal tunnel syndrome. Importance of sensory nerve conduction studies in diagnosis [13].

Chemical compound and disease context of CTS1

• Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine [14].
• All patients had carpal tunnel syndrome, which was bilateral in 14 of them; 4 patients also had finger flexor tenosynovitis [15].
• Familial amyloidotic polyneuropathy presenting with carpal tunnel syndrome and a new transthyretin mutation, asparagine 70 [16].
• Two cases of lithium-induced hypothyroidism, presenting as carpal tunnel syndrome, are reported [17].
• Eighteen patients with diabetes mellitus, some of whom had variously retinopathy, pregnancy, and the carpal tunnel syndrome, and were variously treated with steroids and vitamin B6, have been overviewed for periods of 8 months to 28 years [18].

Biological context of CTS1

• CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties [19].
• In summary, Ad-CTS1 induces an unusual type of cell death that appears to be independent of BCL-2 family proteins, cytochrome c release, and caspases [1].
• Here, we report that an adenovirus encoding CTS1 (Ad-CTS1) induces growth arrest and loss of viability in all glioma cell lines examined, in the absence of specific cell cycle changes [1].
• Furthermore, both in vitro and in vivo, we have shown that this higher inhibition of tumor growth with the CTS1 vector was correlated with a higher induction of apoptosis [2].
• The 44% prevalence, early age of onset, and equal sex ratio differ from idiopathic carpal tunnel syndrome [20].

Anatomical context of CTS1

• Amyloid fibril proteins were isolated from connective tissues forming carpal tunnels in hemodialysis patients with carpal tunnel syndrome [21].
• 50 woke up at night due to paraesthesiae (with or without numbness or pain) in the fingers innervated by the median nerve (CTS symptoms) in 93 hands [22].
• Riboflavin for 5 months caused nearly complete disappearance of the CTS and caused no change in the specific activity of erythrocyte glutamic-oxaloacetic transaminase [23].
• Carpal tunnel syndrome associated with mixed calcium pyrophosphate dihydrate and apatite crystal deposition in tendon synovial sheath [24].
• The most frequent disorder was rotator cuff syndrome followed by carpal tunnel syndrome and lateral epicondylitis [25].

Associations of CTS1 with chemical compounds

• Pyridoxine in carpal tunnel syndrome [26].
• Biochemical evidence for a deficiency of vitamin B6 in the carpal tunnel syndrome based on a crossover clinical study [27].
• The clinical response, appraised by the diminution of the symptoms of CTS, was correlated only with the restored levels of the transaminase which presumably results from a translational long-term increase in the number of molecules of EGOT by a mechanism activated by correcting a deficiency of pyridoxal 5'-phosphate [14].
• Amyloid deposits were demonstrated by light microscopy in the synovium of the finger flexor tendon and/or transverse carpal ligament of all patients who had surgery for carpal tunnel syndrome, and in the synovium and capsula of the 2 surgically removed hips [15].
• Surgery versus steroid injection in carpal tunnel syndrome: comment on the article by Ly-Pen et al [28].

Regulatory relationships of CTS1

• We previously reported that an adenovirus expressing CTS-1 (Ad-CTS-1) has superior cell death-inducing activity in glioma cells compared with wild-type p53 [29].
• The objective of this study was to determine whether cyclooxygenase-2 (COX-2) is up-regulated in the synovium of patients with carpal tunnel syndrome [30].

Other interactions of CTS1

• CTS1 is an artificial p53-based gene designed to resist various pathways of p53 inactivation [1].
• Ad-CTS1 synergizes with radiotherapy and CD95 ligand in killing glioma cells [1].
• Single-strand conformation polymorphism (SSCP) was analyzed to detect a mutation in the transthyretin (TTR) gene from the mother and son showing polyneuropathy with carpal tunnel syndrome [31].
• Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients [32].
• On review, none had a picture of rheumatoid arthritis, but three patients had developed carpal tunnel syndrome [33].

Analytical, diagnostic and therapeutic context of CTS1

• Thus, CTS1 is an improved tumor suppressor and an alternative for the treatment of wild-type p53-resistant human tumors by gene therapy [19].
• Carpal tunnel syndrome in patients undergoing maintenance hemodialysis [34].
• CONCLUSIONS: Hand symptom diagrams, hypalgesia, and thumb abduction strength testing are helpful in establishing the [corrected] electrodiagnosis of CTS [4].
• OBJECTIVE: To systematically review the precision and accuracy of history taking and physical examination in diagnosing CTS in adults [4].
• Yoga for carpal tunnel syndrome [35].

References