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Swerdlow, N.R. et al.

Swerdlow, Shoemaker, Pitcher, Platten, Kuczenski, Eleey, Auerbach,

Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediation.

Strain differences in sensitivity to dopamine agonist-induced disruption of prepulse inhibition (PPI) may be a useful model for the genetics of PPI deficits in neuropsychiatric disorders. Compared with Long-Evans (LE) rats, Sprague-Dawley (SD) rats are more sensitive to the PPI-disruptive effects of the DA agonist apomorphine. The authors tested the hypothesis that this strain difference reflects brain function rather than peripheral physiology. Significant SD > LE PPI-disruptive effects of apomorphine were observed despite equal apomorphine levels in SD and LE rats in forebrain regions that regulate PPI. SD > LE PPI-disruptive effects of apomorphine were also independent of peripheral versus central route of administration. This model for PPI genetics is sensitive to differences in central rather than peripheral substrates.[1]

References

Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediation. Swerdlow, N.R., Shoemaker, J.M., Pitcher, L., Platten, A., Kuczenski, R., Eleey, C.C., Auerbach, P. Behav. Neurosci. (2002) [Pubmed]

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