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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tying rings for sex.

The primary component of the sex pilus encoded by IncP ( RP4) and Ti plasmids has been identified as a circular pilin protein with a peptide bond between the amino and carboxyl terminus. Here, we review the key experiments that led to this discovery, and the present mechanistic model for pilin-precursor processing and the cyclization reaction. In addition, we discuss the implications for horizontal gene transfer in bacterial conjugation.[1]

References

  1. Tying rings for sex. Kalkum, M., Eisenbrandt, R., Lurz, R., Lanka, E. Trends Microbiol. (2002) [Pubmed]
 
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