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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction.

Microtubule-associated protein 2 (MAP2) is a major component of cross-bridges between microtubules in dendrites, and is known to stabilize microtubules. MAP2 also has a binding domain for the regulatory subunit II of cAMP-dependent protein kinase (PKA). We found that there is reduction in microtubule density in dendrites and a reduction of dendritic length in MAP2-deficient mice. Moreover, there is a significant reduction of various subunits of PKA in dendrites and total amounts of various PKA subunits in hippocampal tissue and cultured neurons. In MAP2-deficient cultured neurons, the induction rate of phosphorylated CREB after forskolin stimulation was much lower than in wild-type neurons. Therefore, MAP2 is an anchoring protein of PKA in dendrites, whose loss leads to reduced amount of dendritic and total PKA and reduced activation of CREB.[1]

References

  1. MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. Harada, A., Teng, J., Takei, Y., Oguchi, K., Hirokawa, N. J. Cell Biol. (2002) [Pubmed]
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