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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B.

Parathyroid hormone-related protein (PTHrP) has a diverse range of proposed biological activities participating in both extracellular and intracellular signaling. In order to identify candidate protein effectors, yeast two-hybrid screens were conducted using mature human PTHrP (residues 1-141) and the COOH-terminus (residues 107-141). Both PTHrP baits interacted with a beta-arrestin 1B fragment, an important component of G-protein-coupled receptor desensitization and MAPK signaling. Co-immunoprecipitation, in vitro binding assays and colocalization experiments confirmed this interaction in human cells and this required residues 122-141 of PTHrP. These findings suggest that beta-arrestin 1 acts as an effector for a novel function of PTHrP in cytoplasm.[1]

References

  1. The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B. Conlan, L.A., Martin, T.J., Gillespie, M.T. FEBS Lett. (2002) [Pubmed]
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