Gene Review:
PTH - parathyroid hormone
Homo sapiens
Synonyms:
PTH1, Parathormone, Parathyrin, Parathyroid hormone
- Effect of parathyroid hormone on erythropoiesis. Meytes, D., Bogin, E., Ma, A., Dukes, P.P., Massry, S.G. J. Clin. Invest. (1981)
- Vitamin D physiology. Lips, P. Prog. Biophys. Mol. Biol. (2006)
- Co-secretion of parathyroid hormone and parathyroid-hormone-related protein via a regulated pathway in human parathyroid adenoma cells. Matsushita, H., Usui, M., Hara, M., Shishiba, Y., Nakazawa, H., Honda, K., Torigoe, K., Kohno, K., Kurimoto, M. Am. J. Pathol. (1997)
- Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands. Huan, J., Olgaard, K., Nielsen, L.B., Lewin, E. J. Am. Soc. Nephrol. (2006)
- Parathyroid hormone/parathyroid hormone-related peptide type 1 receptor in human bone. Langub, M.C., Monier-Faugere, M.C., Qi, Q., Geng, Z., Koszewski, N.J., Malluche, H.H. J. Bone Miner. Res. (2001)
- Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone. Roh, J.L., Park, J.Y., Park, C.I. Ann. Surg. (2007)
- Vitamin D and estrogen receptor-alpha genotype and indices of bone mass and bone turnover in Danish girls. Cusack, S., Mølgaard, C., Michaelsen, K.F., Jakobsen, J., Lamberg-Allardt, C.J., Cashman, K.D. J. Bone Miner. Metab. (2006)
- A case of chromosome 22q11 deletion syndrome diagnosed in a 32-year-old man with hypoparathyroidism. Maalouf, N.M., Sakhaee, K., Odvina, C.V. J. Clin. Endocrinol. Metab. (2004)
- Association of polymorphic alleles of the calcium-sensing receptor gene with parathyroid hormone secretion in hemodialysis patients. Yano, S., Sugimoto, T., Kanzawa, M., Tsukamoto, T., Hattori, T., Hattori, S., Chihara, K. Nephron (2000)
- Effect of smoking and smoking cessation on bone mass, bone remodeling, vitamin D, PTH and sex hormones. Supervia, A., Nogues, X., Enjuanes, A., Vila, J., Mellibovsky, L., Serrano, S., Aubia, J., Diez-Perez, A. Journal of musculoskeletal & neuronal interactions (2006)
- Hypoparathyroidism in chronic alcohol intoxication: a preliminary report. Manfredini, R., Bariani, L., Bagni, B., Cavallini, A.R., Gallerani, M., Salmi, R., Pasin, M., Cecchetti, E., Rosini, M., Franceschini, F. Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue européenne pour les sciences médicales et pharmacologiques. (1992)
- Calcium: taste, intake, and appetite. Tordoff, M.G. Physiol. Rev. (2001)
- A mutant PTH/PTHrP type I receptor in enchondromatosis. Hopyan, S., Gokgoz, N., Poon, R., Gensure, R.C., Yu, C., Cole, W.G., Bell, R.S., Jüppner, H., Andrulis, I.L., Wunder, J.S., Alman, B.A. Nat. Genet. (2002)
- Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer, R.M., Arnaud, C.D., Zanchetta, J.R., Prince, R., Gaich, G.A., Reginster, J.Y., Hodsman, A.B., Eriksen, E.F., Ish-Shalom, S., Genant, H.K., Wang, O., Mitlak, B.H. N. Engl. J. Med. (2001)
- Effects of inhaled glucocorticoids on bone density in premenopausal women. Israel, E., Banerjee, T.R., Fitzmaurice, G.M., Kotlov, T.V., LaHive, K., LeBoff, M.S. N. Engl. J. Med. (2001)
- Efficacy and specificity of human parathyroid hormone analogues as antagonists in intact clonal osteogenic sarcoma cells. Kubota, M., Ng, K.W., Murase, J., Noda, T., Moseley, J.M., Martin, T.J. J. Endocrinol. (1986)
- Inhibition of renal adenylate cyclase by plasma from uremic patients. Jüppner, H., Hesch, R.D. J. Endocrinol. Invest. (1982)
- Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy. Schilling, T., Pecherstorfer, M., Blind, E., Leidig, G., Ziegler, R., Raue, F. J. Clin. Endocrinol. Metab. (1993)
- Direct modulation by androgens of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein. Fukayama, S., Tashjian, A.H. Endocrinology (1989)
- Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. Yates, A.J., Gutierrez, G.E., Smolens, P., Travis, P.S., Katz, M.S., Aufdemorte, T.B., Boyce, B.F., Hymer, T.K., Poser, J.W., Mundy, G.R. J. Clin. Invest. (1988)
- Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Fu, Q., Manolagas, S.C., O'Brien, C.A. Mol. Cell. Biol. (2006)
- Distinct beta-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation. Gesty-Palmer, D., Chen, M., Reiter, E., Ahn, S., Nelson, C.D., Wang, S., Eckhardt, A.E., Cowan, C.L., Spurney, R.F., Luttrell, L.M., Lefkowitz, R.J. J. Biol. Chem. (2006)
- Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T., Martin, T.J. Endocr. Rev. (1999)
- Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Kim, S., Yamazaki, M., Zella, L.A., Shevde, N.K., Pike, J.W. Mol. Cell. Biol. (2006)
- Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion. Sowa, H., Kaji, H., Kitazawa, R., Kitazawa, S., Tsukamoto, T., Yano, S., Tsukada, T., Canaff, L., Hendy, G.N., Sugimoto, T., Chihara, K. Cancer Res. (2004)
- Nurse-like cells from patients with rheumatoid arthritis support the survival of osteoclast precursors via macrophage colony-stimulating factor production. Tsuboi, H., Udagawa, N., Hashimoto, J., Yoshikawa, H., Takahashi, N., Ochi, T. Arthritis Rheum. (2005)
- Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. Nissenson, R.A., Diep, D., Strewler, G.J. J. Biol. Chem. (1988)
- Functional expression and signaling properties of cloned human parathyroid hormone receptor in Xenopus oocytes. Evidence for a novel signaling pathway. Tong, Y., Zull, J., Yu, L. J. Biol. Chem. (1996)
- Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts. Hilal, G., Massicotte, F., Martel-Pelletier, J., Fernandes, J.C., Pelletier, J.P., Lajeunesse, D. J. Bone Miner. Res. (2001)
- Solid-phase synthesis and biologic activity of human parathyroid hormone (1-84). Goud, N.A., McKee, R.L., Sardana, M.K., DeHaven, P.A., Huelar, E., Syed, M.M., Goud, R.A., Gibbons, S.W., Fisher, J.E., Levy, J.J. J. Bone Miner. Res. (1991)
- Regulation of PTH1 receptor expression by uremic ultrafiltrate in UMR 106-01 osteoblast-like cells. Disthabanchong, S., Hassan, H., McConkey, C.L., Martin, K.J., Gonzalez, E.A. Kidney Int. (2004)
- G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Offermanns, S., Iida-Klein, A., Segre, G.V., Simon, M.I. Mol. Endocrinol. (1996)
- The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Shimada, M., Mahon, M.J., Greer, P.A., Segre, G.V. Endocrinology (2005)
- Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor. Dean, T., Vilardaga, J.P., Potts, J.T., Gardella, T.J. Mol. Endocrinol. (2008)
- In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor. Lazure, C., Gauthier, D., Jean, F., Boudreault, A., Seidah, N.G., Bennett, H.P., Hendy, G.N. J. Biol. Chem. (1998)
- Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization. Malecz, N., Bambino, T., Bencsik, M., Nissenson, R.A. Mol. Endocrinol. (1998)
- Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Nashiki, K., Taketani, Y., Takeichi, T., Sawada, N., Yamamoto, H., Ichikawa, M., Arai, H., Miyamoto, K., Takeda, E. Kidney Int. (2005)
- CYP2D6, GST-M1 and GST-T1 enzymes: expression in parathyroid gland and association with the parathyroid hormone concentration during early renal replacement therapy. Yan, F.X., Langub, M.C., Ihnen, M.A., Hornung, C., Juronen, E., Rayens, M.K., Cai, W.M., Wedlund, P.J., Fanti, P. British journal of clinical pharmacology. (2003)
- Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. Bisello, A., Manen, D., Pierroz, D.D., Usdin, T.B., Rizzoli, R., Ferrari, S.L. Mol. Endocrinol. (2004)
- In vivo demonstration that human parathyroid hormone 1-38 inhibits the expression of osteoprotegerin in bone with the kinetics of an immediate early gene. Onyia, J.E., Miles, R.R., Yang, X., Halladay, D.L., Hale, J., Glasebrook, A., McClure, D., Seno, G., Churgay, L., Chandrasekhar, S., Martin, T.J. J. Bone Miner. Res. (2000)
- Renal vasodilatation and microvessel adenylate cyclase stimulation by synthetic parathyroid hormone-like protein fragments. Musso, M.J., Plante, M., Judes, C., Barthelmebs, M., Helwig, J.J. Eur. J. Pharmacol. (1989)
- Vitamin D and bone. Suda, T., Ueno, Y., Fujii, K., Shinki, T. J. Cell. Biochem. (2003)
- Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Castro, M., Nikolaev, V.O., Palm, D., Lohse, M.J., Vilardaga, J.P. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. Usdin, T.B., Gruber, C., Bonner, T.I. J. Biol. Chem. (1995)
- Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts. Chen, C., Koh, A.J., Datta, N.S., Zhang, J., Keller, E.T., Xiao, G., Franceschi, R.T., D'Silva, N.J., McCauley, L.K. J. Biol. Chem. (2004)
- Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia. Ratcliffe, W.A., Hutchesson, A.C., Bundred, N.J., Ratcliffe, J.G. Lancet (1992)
- Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. Hendy, G.N., Bennett, H.P., Gibbs, B.F., Lazure, C., Day, R., Seidah, N.G. J. Biol. Chem. (1995)
- Hyperparathyroidism in hereditary syndromes: special expressions and special managements. Marx, S.J., Simonds, W.F., Agarwal, S.K., Burns, A.L., Weinstein, L.S., Cochran, C., Skarulis, M.C., Spiegel, A.M., Libutti, S.K., Alexander, H.R., Chen, C.C., Chang, R., Chandrasekharappa, S.C., Collins, F.S. J. Bone Miner. Res. (2002)
- Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. Faucheux, C., Horton, M.A., Price, J.S. J. Bone Miner. Res. (2002)
- Parathyroid hormone gene polymorphism and sporadic idiopathic hypoparathyroidism. Goswami, R., Mohapatra, T., Gupta, N., Rani, R., Tomar, N., Dikshit, A., Sharma, R.K. J. Clin. Endocrinol. Metab. (2004)