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Gene Review

ARRB1  -  arrestin, beta 1

Homo sapiens

Synonyms: ARB1, ARR1, Arrestin beta-1, Beta-arrestin-1
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Disease relevance of ARRB1


Psychiatry related information on ARRB1


High impact information on ARRB1

  • (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters [7].
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin [8].
  • Abrogation of beta-arrestin ubiquitination, either by expression in Mdm2-null cells or by dominant-negative forms of Mdm2 lacking E3 ligase activity, inhibited receptor internalization with marginal effects on receptor degradation [8].
  • These data suggest that beta-arrestin binding, which terminates receptor-G protein coupling, also initiates a second wave of signal transduction in which the "desensitized" receptor functions as a critical structural component of a mitogenic signaling complex [9].
  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes [9].

Biological context of ARRB1


Anatomical context of ARRB1


Associations of ARRB1 with chemical compounds


Physical interactions of ARRB1


Enzymatic interactions of ARRB1

  • In vitro studies demonstrated that beta-arrestin-V53D bound better to clathrin than beta-arrestin but was significantly impaired in its interaction with phosphorylated G protein-coupled receptors [26].

Co-localisations of ARRB1


Regulatory relationships of ARRB1


Other interactions of ARRB1


Analytical, diagnostic and therapeutic context of ARRB1


  1. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. Ge, L., Shenoy, S.K., Lefkowitz, R.J., DeFea, K. J. Biol. Chem. (2004) [Pubmed]
  2. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. Girnita, L., Shenoy, S.K., Sehat, B., Vasilcanu, R., Girnita, A., Lefkowitz, R.J., Larsson, O. J. Biol. Chem. (2005) [Pubmed]
  3. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Buchanan, F.G., Gorden, D.L., Matta, P., Shi, Q., Matrisian, L.M., DuBois, R.N. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Binding of purified recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled receptors. Söhlemann, P., Hekman, M., Puzicha, M., Buchen, C., Lohse, M.J. Eur. J. Biochem. (1995) [Pubmed]
  5. Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Avissar, S., Matuzany-Ruban, A., Tzukert, K., Schreiber, G. The American journal of psychiatry. (2004) [Pubmed]
  6. The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders. Iacovelli, L., Fulceri, F., De Blasi, A., Nicoletti, F., Ruggieri, S., Fornai, F. Exp. Neurol. (2006) [Pubmed]
  7. Beta-arrestin goes nuclear. Beaulieu, J.M., Caron, M.G. Cell (2005) [Pubmed]
  8. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Shenoy, S.K., McDonald, P.H., Kohout, T.A., Lefkowitz, R.J. Science (2001) [Pubmed]
  9. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Luttrell, L.M., Ferguson, S.S., Daaka, Y., Miller, W.E., Maudsley, S., Della Rocca, G.J., Lin, F., Kawakatsu, H., Owada, K., Luttrell, D.K., Caron, M.G., Lefkowitz, R.J. Science (1999) [Pubmed]
  10. Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13. Calabrese, G., Sallese, M., Stornaiuolo, A., Morizio, E., Palka, G., De Blasi, A. Genomics (1994) [Pubmed]
  11. Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. Penela, P., Elorza, A., Sarnago, S., Mayor, F. EMBO J. (2001) [Pubmed]
  12. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Kim, J., Ahn, S., Ren, X.R., Whalen, E.J., Reiter, E., Wei, H., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Witherow, D.S., Garrison, T.R., Miller, W.E., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  14. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Azzi, M., Charest, P.G., Angers, S., Rousseau, G., Kohout, T., Bouvier, M., Piñeyro, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. Barnes, W.G., Reiter, E., Violin, J.D., Ren, X.R., Milligan, G., Lefkowitz, R.J. J. Biol. Chem. (2005) [Pubmed]
  16. A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. Ge, L., Ly, Y., Hollenberg, M., DeFea, K. J. Biol. Chem. (2003) [Pubmed]
  17. Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor. Kim, S.J., Kim, M.Y., Lee, E.J., Ahn, Y.S., Baik, J.H. Mol. Endocrinol. (2004) [Pubmed]
  18. Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, beta-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes. Giorelli, M., Livrea, P., Defazio, G., Iacovelli, L., Capobianco, L., Picascia, A., Sallese, M., Martino, D., Aniello, M.S., Trojano, M., De Blasi, A. Cell. Signal. (2002) [Pubmed]
  19. Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. Braun, L., Christophe, T., Boulay, F. J. Biol. Chem. (2003) [Pubmed]
  20. RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G., Houslay, M.D. J. Biol. Chem. (2005) [Pubmed]
  21. A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors. Gong, K., Li, Z., Xu, M., Du, J., Lv, Z., Zhang, Y. J. Biol. Chem. (2008) [Pubmed]
  22. The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B. Conlan, L.A., Martin, T.J., Gillespie, M.T. FEBS Lett. (2002) [Pubmed]
  23. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. Claing, A., Chen, W., Miller, W.E., Vitale, N., Moss, J., Premont, R.T., Lefkowitz, R.J. J. Biol. Chem. (2001) [Pubmed]
  24. Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. Cen, B., Yu, Q., Guo, J., Wu, Y., Ling, K., Cheng, Z., Ma, L., Pei, G. J. Neurochem. (2001) [Pubmed]
  25. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Bolger, G.B., Baillie, G.S., Li, X., Lynch, M.J., Herzyk, P., Mohamed, A., Mitchell, L.H., McCahill, A., Hundsrucker, C., Klussmann, E., Adams, D.R., Houslay, M.D. Biochem. J. (2006) [Pubmed]
  26. Modulation of the arrestin-clathrin interaction in cells. Characterization of beta-arrestin dominant-negative mutants. Krupnick, J.G., Santini, F., Gagnon, A.W., Keen, J.H., Benovic, J.L. J. Biol. Chem. (1997) [Pubmed]
  27. Beta-arrestin is involved in the desensitization but not in the internalization of the somatostatin receptor 2A expressed in CHO cells. Brasselet, S., Guillen, S., Vincent, J.P., Mazella, J. FEBS Lett. (2002) [Pubmed]
  28. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. Freedman, N.J., Liggett, S.B., Drachman, D.E., Pei, G., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1995) [Pubmed]
  29. c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Fessart, D., Simaan, M., Laporte, S.A. Mol. Endocrinol. (2005) [Pubmed]
  30. Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. Oakley, R.H., Laporte, S.A., Holt, J.A., Barak, L.S., Caron, M.G. J. Biol. Chem. (2001) [Pubmed]
  31. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. Vilardaga, J.P., Krasel, C., Chauvin, S., Bambino, T., Lohse, M.J., Nissenson, R.A. J. Biol. Chem. (2002) [Pubmed]
  32. Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Aragay, A.M., Mellado, M., Frade, J.M., Martin, A.M., Jimenez-Sainz, M.C., Martinez-A, C., Mayor, F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  33. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. Daaka, Y., Luttrell, L.M., Ahn, S., Della Rocca, G.J., Ferguson, S.S., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1998) [Pubmed]
  34. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Ungerer, M., Parruti, G., Böhm, M., Puzicha, M., DeBlasi, A., Erdmann, E., Lohse, M.J. Circ. Res. (1994) [Pubmed]
  35. Homologous desensitization of signalling by the beta (beta) isoform of the human thromboxane A(2) receptor. Kelley-Hickie, L.P., Kinsella, B.T. Biochim. Biophys. Acta (2006) [Pubmed]
  36. Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. Tseng, C.C., Zhang, X.Y. Endocrinology (2000) [Pubmed]
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