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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site.

Previously unrecognized mRNAs originating from a dual promoter at the stat92E locus are described. One of these encodes a truncated protein, DeltaNSTAT92E, that lacks the N-terminal 133 amino acids. Antibodies detect both the full-length and truncated molecules early in embryogenesis (1-5 h), and mRNA detection by specific RT-PCR reactions accords with the protein distribution. Given that the N termini of mammalian STATs are known to have positive functions in transcriptional activation, we explored the role of DeltaNSTAT92E early in embryogenesis. By increasing the DeltaNSTAT92E-to-STAT92E ratio in overexpression and RNAi experiments, we observe phenotypes compatible with suppression of wild-type STAT92E activity. We therefore conclude that the short form of STAT92E is a naturally occurring dominant-negative product that can be added to the growing list of negative regulators of STAT activity.[1]

References

  1. Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site. Henriksen, M.A., Betz, A., Fuccillo, M.V., Darnell, J.E. Genes Dev. (2002) [Pubmed]
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