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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Altenbach, R.J. et al.

Altenbach, Khilevich, Meyer, Buckner, Milicic, Daza, Brune, O'Neill, Gauvin, Cain, Nakane, Holladay, Williams, Brioni, Sullivan,

N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.

N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1) is a novel alpha(1) agent having the unique profile of alpha(1A) (rabbit urethra, EC(50) = 0.60 microM) agonism with alpha(1B) (rat spleen, pA(2) = 5.4) and alpha(1D) (rat aorta, pA(2) = 6.2) antagonism. An in vivo dog model showed 1 to be more selective for the urethra over the vasculature than A-61603 (2), ST-1059 (3, the active metabolite of midodrine), and phenylpropanolamine (4).[1]

References

N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. Altenbach, R.J., Khilevich, A., Meyer, M.D., Buckner, S.A., Milicic, I., Daza, A.V., Brune, M.E., O'Neill, A.B., Gauvin, D.M., Cain, J.C., Nakane, M., Holladay, M.W., Williams, M., Brioni, J.D., Sullivan, J.P. J. Med. Chem. (2002) [Pubmed]

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