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Chemical Compound Review

Midodrin     2-amino-N-[2-(2,5- dimethoxyphenyl)-2...

Synonyms: Alphamine, Midodrina, midodrine, Midodrinum, ProAmatine, ...
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Disease relevance of midodrine


Psychiatry related information on midodrine


High impact information on midodrine


Chemical compound and disease context of midodrine


Biological context of midodrine


Anatomical context of midodrine


Associations of midodrine with other chemical compounds


Gene context of midodrine

  • The human cytochrome P450 (CYP) isoforms catalyzing the oxidation metabolism of desglymidodrine (DMAE), an active metabolite of midodrine, were studied [26].
  • The uptake of midodrine, but not DMAE, was markedly increased in PEPT1-expressing oocytes compared with water-injected oocytes [22].
  • We report the use of midodrine, an alpha agonist, in an 18-year-old man with Bardet-Biedl syndrome and recurrent intradialytic hypotension [27].
  • To clarify the effect of a long-acting selective alpha 1-adrenoceptive sympathomimetic agent on sympathetic outflow to muscles (muscle sympathetic activity, MSA) in humans, 5 mg of midodrine hydrochloride was injected intravenously in ten healthy male subjects aged 19-25 [28].
  • Ischemic calf exercise evoked similar peak CBF in both trials, but midodrine reduced the hyperemic response over 5 min of recovery (P < 0.02) [29].

Analytical, diagnostic and therapeutic context of midodrine


  1. Efficacy of midodrine for neurogenic orthostatic hypotension. Berlin, I. JAMA (1997) [Pubmed]
  2. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Jacob, G., Shannon, J.R., Black, B., Biaggioni, I., Mosqueda-Garcia, R., Robertson, R.M., Robertson, D. Circulation (1997) [Pubmed]
  3. Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study. Kaufmann, H., Saadia, D., Voustianiouk, A. Ann. Neurol. (2002) [Pubmed]
  4. Acute effects of the oral administration of midodrine, an alpha-adrenergic agonist, on renal hemodynamics and renal function in cirrhotic patients with ascites. Angeli, P., Volpin, R., Piovan, D., Bortoluzzi, A., Craighero, R., Bottaro, S., Finucci, G.F., Casiglia, E., Sticca, A., De Toni, R., Pavan, L., Gatta, A. Hepatology (1998) [Pubmed]
  5. Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide. Angeli, P., Volpin, R., Gerunda, G., Craighero, R., Roner, P., Merenda, R., Amodio, P., Sticca, A., Caregaro, L., Maffei-Faccioli, A., Gatta, A. Hepatology (1999) [Pubmed]
  6. Acute dystonia induced by adding midodrine, a selective alpha 1 agonist, to risperidone in a patient with catatonic schizophrenia. Takahashi, H. The Journal of neuropsychiatry and clinical neurosciences. (2000) [Pubmed]
  7. Central action of intraventricularly-injected midodrine in rats. Kleinrok, Z., Jagiełło-Wójtowicz, E., Oktaba-Polkowska, A. Archives internationales de pharmacodynamie et de thérapie. (1980) [Pubmed]
  8. Diagnosis and treatment of diabetic autonomic neuropathy. Ziegler, D. Curr. Diab. Rep. (2001) [Pubmed]
  9. Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome. Wong, F., Pantea, L., Sniderman, K. Hepatology (2004) [Pubmed]
  10. Pyridostigmine treatment trial in neurogenic orthostatic hypotension. Singer, W., Sandroni, P., Opfer-Gehrking, T.L., Suarez, G.A., Klein, C.M., Hines, S., O'Brien, P.C., Slezak, J., Low, P.A. Arch. Neurol. (2006) [Pubmed]
  11. Putting it together: a new treatment algorithm for vasovagal syncope and related disorders. Bloomfield, D.M., Sheldon, R., Grubb, B.P., Calkins, H., Sutton, R. Am. J. Cardiol. (1999) [Pubmed]
  12. Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. Senard, J.M., Arias, A., Berlan, M., Tran, M.A., Rascol, A., Montastruc, J.L. Eur. J. Clin. Pharmacol. (1991) [Pubmed]
  13. Idiopathic orthostatic hypotension, midodrine, and anaesthesia. Osborne, P.J., Lee, L.W. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1991) [Pubmed]
  14. Vasoconstrictor therapy for hepatorenal syndrome in liver cirrhosis. Schmidt, L.E., Ring-Larsen, H. Curr. Pharm. Des. (2006) [Pubmed]
  15. Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group. Low, P.A., Gilden, J.L., Freeman, R., Sheng, K.N., McElligott, M.A. JAMA (1997) [Pubmed]
  16. Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Fouad-Tarazi, F.M., Okabe, M., Goren, H. Am. J. Med. (1995) [Pubmed]
  17. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Wright, R.A., Kaufmann, H.C., Perera, R., Opfer-Gehrking, T.L., McElligott, M.A., Sheng, K.N., Low, P.A. Neurology (1998) [Pubmed]
  18. Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. McTavish, D., Goa, K.L. Drugs (1989) [Pubmed]
  19. Treatment of orthostatic hypotension due to autonomic failure with a peripheral alpha-adrenergic agonist (midodrine). Kaufmann, H., Brannan, T., Krakoff, L., Yahr, M.D., Mandeli, J. Neurology (1988) [Pubmed]
  20. N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. Altenbach, R.J., Khilevich, A., Meyer, M.D., Buckner, S.A., Milicic, I., Daza, A.V., Brune, M.E., O'Neill, A.B., Gauvin, D.M., Cain, J.C., Nakane, M., Holladay, M.W., Williams, M., Brioni, J.D., Sullivan, J.P. J. Med. Chem. (2002) [Pubmed]
  21. Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via alpha-mediated mechanisms. Felsner, P., Hofer, D., Rinner, I., Mangge, H., Gruber, M., Korsatko, W., Schauenstein, K. J. Neuroimmunol. (1992) [Pubmed]
  22. Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. Tsuda, M., Terada, T., Irie, M., Katsura, T., Niida, A., Tomita, K., Fujii, N., Inui, K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  23. Recent advances in the treatment of orthostatic hypotension. Robertson, D., Davis, T.L. Neurology (1995) [Pubmed]
  24. Urodynamic analysis of age-related changes of alpha 1-adrenoceptor responsiveness in female beagle dogs. Takahashi, S., Moriyama, N., Yamazaki, R., Kawabe, K. J. Urol. (1996) [Pubmed]
  25. Orthostatic hypotension in patients, bed rest subjects, and astronauts. Lathers, C.M., Charles, J.B. Journal of clinical pharmacology. (1994) [Pubmed]
  26. The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. Akimoto, M., Iida, I., Itoga, H., Miyata, A., Kawahara, S., Kohno, Y. European journal of drug metabolism and pharmacokinetics. (2004) [Pubmed]
  27. Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. Blowey, D.L., Balfe, J.W., Gupta, I., Gajaria, M.M., Koren, G. Am. J. Kidney Dis. (1996) [Pubmed]
  28. Long-acting alpha 1-adrenoceptive sympathomimetic agent suppresses sympathetic outflow to muscles in humans. Iwase, S., Mano, T., Saito, M., Ishida, G. J. Auton. Nerv. Syst. (1991) [Pubmed]
  29. Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure. Schrage, W.G., Eisenach, J.H., Dinenno, F.A., Roberts, S.K., Johnson, C.P., Sandroni, P., Low, P.A., Joyner, M.J. J. Appl. Physiol. (2004) [Pubmed]
  30. Intradialytic hypotension: is midodrine beneficial in symptomatic hemodialysis patients? Cruz, D.N., Mahnensmith, R.L., Perazella, M.A. Am. J. Kidney Dis. (1997) [Pubmed]
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