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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney.

The light mitochondrial fraction of hypoxic rodent kidneys, called the renal erythropoietic factor, contains erythropoietin in a pro, or active form. Erythropoietin is released from this inactive form when the renal erythropoietic factor is incubated with normal serum. The biogenesis of erythropoietin possibly involves a system in kidney reminiscent of the proinsulin-insulin system in pancreas.[1]


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