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Peschle, C. et al.

Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney.

The light mitochondrial fraction of hypoxic rodent kidneys, called the renal erythropoietic factor, contains erythropoietin in a pro, or active form. Erythropoietin is released from this inactive form when the renal erythropoietic factor is incubated with normal serum. The biogenesis of erythropoietin possibly involves a system in kidney reminiscent of the proinsulin-insulin system in pancreas.[1]

References

Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney. Peschle, C., Condorelli, M. Science (1975) [Pubmed]

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