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MeSH Review

Subcellular Fractions

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Disease relevance of Subcellular Fractions


Psychiatry related information on Subcellular Fractions


High impact information on Subcellular Fractions

  • Two lines of independently derived PrPC gene-ablated (Prnp0/0) mice exhibit severe reductions in the copper content of membrane-enriched brain extracts and similar reductions in synaptosomal and endosome-enriched subcellular fractions [8].
  • Early data showed that styrene oxide hydrolase activity was associate with the microsomal subcellular fraction [9].
  • The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium [10].
  • Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney [11].
  • The calculated apparent Km for NADPH was equivalent in the two fractions, but the Vmax was increased 2.5-fold in the subcellular fraction from LPS-pretreated cells [12].

Chemical compound and disease context of Subcellular Fractions


Biological context of Subcellular Fractions


Anatomical context of Subcellular Fractions


Associations of Subcellular Fractions with chemical compounds


Gene context of Subcellular Fractions


Analytical, diagnostic and therapeutic context of Subcellular Fractions


  1. Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice. Shaposhnikov, J.D., Shalumovich, W.N., Kisselev, O.I., Gaitskhoki, V.S., Pozharisski, K.M. J. Natl. Cancer Inst. (1976) [Pubmed]
  2. Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid. Oftebro, H., Björkhem, I., Skrede, S., Schreiner, A., Pederson, J.I. J. Clin. Invest. (1980) [Pubmed]
  3. Proteolytic enzymes in tumor metastasis. II. Collagenase type IV activity in subcellular fractions of cloned tumor cell populations. Eisenbach, L., Segal, S., Feldman, M. J. Natl. Cancer Inst. (1985) [Pubmed]
  4. Deficient flavoprotein component of the NADPH-dependent O2-.-generating oxidase in the neutrophils from three male patients with chronic granulomatous disease. Gabig, T.G., Lefker, B.A. J. Clin. Invest. (1984) [Pubmed]
  5. Effects of short-term pancreatic duct obstruction in rats. Ohshio, G., Saluja, A., Steer, M.L. Gastroenterology (1991) [Pubmed]
  6. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Weiler, I.J., Irwin, S.A., Klintsova, A.Y., Spencer, C.M., Brazelton, A.D., Miyashiro, K., Comery, T.A., Patel, B., Eberwine, J., Greenough, W.T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains. Wenstrup, D., Ehmann, W.D., Markesbery, W.R. Brain Res. (1990) [Pubmed]
  8. The cellular prion protein binds copper in vivo. Brown, D.R., Qin, K., Herms, J.W., Madlung, A., Manson, J., Strome, R., Fraser, P.E., Kruck, T., von Bohlen, A., Schulz-Schaeffer, W., Giese, A., Westaway, D., Kretzschmar, H. Nature (1997) [Pubmed]
  9. Epoxide hydrolase activity in the mitochondrial fraction of mouse liver. Gill, S.S., Hammock, B.D. Nature (1981) [Pubmed]
  10. Calmodulin activation of adenylate cyclase in pancreatic islets. Valverde, I., Vandermeers, A., Anjaneyulu, R., Malaisse, W.J. Science (1979) [Pubmed]
  11. Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney. Peschle, C., Condorelli, M. Science (1975) [Pubmed]
  12. Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme. Guthrie, L.A., McPhail, L.C., Henson, P.M., Johnston, R.B. J. Exp. Med. (1984) [Pubmed]
  13. Membrane lipids of hepatic tissue. I. Neutral lipids from subcellular fractions of liver and hepatoma 7288CTC. Upreti, G.C., deAntueno, R.J., Wood, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  14. Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. Craven, P.A., DeRubertis, F.R. Cancer Res. (1992) [Pubmed]
  15. Coregulation of NADPH oxidase activation and phosphorylation of a 48-kD protein(s) by a cytosolic factor defective in autosomal recessive chronic granulomatous disease. Caldwell, S.E., McCall, C.E., Hendricks, C.L., Leone, P.A., Bass, D.A., McPhail, L.C. J. Clin. Invest. (1988) [Pubmed]
  16. Polarized sorting of rhodopsin on post-Golgi membranes in frog retinal photoreceptor cells. Deretic, D., Papermaster, D.S. J. Cell Biol. (1991) [Pubmed]
  17. Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Yu, W., Cassara, J., Weller, P.F. Blood (2000) [Pubmed]
  18. Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity. Silva, M.H., Wixtrom, R.N., Hammock, B.D. Cancer Res. (1988) [Pubmed]
  19. Metabolism and excretion of benzo(a)pyrene 4,5-oxide by the isolated perfused rat liver. Smith, B.R., Bend, J.R. Cancer Res. (1979) [Pubmed]
  20. Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes. Jesaitis, A.J., Buescher, E.S., Harrison, D., Quinn, M.T., Parkos, C.A., Livesey, S., Linner, J. J. Clin. Invest. (1990) [Pubmed]
  21. Endogenous lectins from cultured cells: subcellular localization of carbohydrate-binding protein 35 in 3T3 fibroblasts. Moutsatsos, I.K., Davis, J.M., Wang, J.L. J. Cell Biol. (1986) [Pubmed]
  22. Analytical study of microsomes and isolated subcellular membranes from rat liver. V. Immunological localization of cytochrome b5 by electron microscopy: methodology and application to various subcellular fractions. Fowler, S., Remacle, J., Trouet, A., Beaufay, H., Berthet, J., Wibo, M., Hauser, P. J. Cell Biol. (1976) [Pubmed]
  23. Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ. Saxon, M.L., Zhao, X., Black, J.D. J. Cell Biol. (1994) [Pubmed]
  24. Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules. Resh, M.D., Erikson, R.L. J. Cell Biol. (1985) [Pubmed]
  25. Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2. Larkin, J.M., Oswald, B., McNiven, M.A. J. Clin. Invest. (1996) [Pubmed]
  26. Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model. Dodd, D.A., Atkinson, J.B., Olson, R.D., Buck, S., Cusack, B.J., Fleischer, S., Boucek, R.J. J. Clin. Invest. (1993) [Pubmed]
  27. Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase. Agwu, D.E., McPhail, L.C., Sozzani, S., Bass, D.A., McCall, C.E. J. Clin. Invest. (1991) [Pubmed]
  28. Mutagenic activation of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in subcellular fractions from X/Gf mice. Reddy, T.V., Weisburger, E.K., Thorgeirsson, S.S. J. Natl. Cancer Inst. (1980) [Pubmed]
  29. Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells. Bokoch, G.M., Prossnitz, V. J. Clin. Invest. (1992) [Pubmed]
  30. Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. de Beus, E., Brockenbrough, J.S., Hong, B., Aris, J.P. J. Cell Biol. (1994) [Pubmed]
  31. CYC2 encodes a factor involved in mitochondrial import of yeast cytochrome c. Dumont, M.E., Schlichter, J.B., Cardillo, T.S., Hayes, M.K., Bethlendy, G., Sherman, F. Mol. Cell. Biol. (1993) [Pubmed]
  32. A novel protein with RNA-binding motifs interacts with ataxin-2. Shibata, H., Huynh, D.P., Pulst, S.M. Hum. Mol. Genet. (2000) [Pubmed]
  33. The role of carboxyl-terminal basic amino acids in Gqalpha-dependent activation, particulate association, and nuclear localization of phospholipase C-beta1. Kim, C.G., Park, D., Rhee, S.G. J. Biol. Chem. (1996) [Pubmed]
  34. Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Leber, R., Landl, K., Zinser, E., Ahorn, H., Spök, A., Kohlwein, S.D., Turnowsky, F., Daum, G. Mol. Biol. Cell (1998) [Pubmed]
  35. Characterization of cytoplasmically oriented Golgi proteins with a monoclonal antibody. Chicheportiche, Y., Vassalli, P., Tartakoff, A.M. J. Cell Biol. (1984) [Pubmed]
  36. Yeast nuclear envelope proteins cross react with an antibody against mammalian pore complex proteins. Aris, J.P., Blobel, G. J. Cell Biol. (1989) [Pubmed]
  37. The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. Kaw, S., Hecker, M., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  38. Localizaton of fibrin converted by thrombin from released platelet fibrinogen. Chao, F.C., Campo, S.R., Kenney, D.M. Blood (1980) [Pubmed]
  39. Intracellular localization of interleukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma. Lacy, P., Levi-Schaffer, F., Mahmudi-Azer, S., Bablitz, B., Hagen, S.C., Velazquez, J., Kay, A.B., Moqbel, R. Blood (1998) [Pubmed]
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