Gene Review:
Epo - erythropoietin
Mus musculus
Synonyms:
Erythropoietin
Korotkova,
Yakushenko,
Diaz,
Hasselblatt,
Xie,
Sirén,
Nave,
Coleman,
Fratelli,
Su-Rick,
Vehmeyer,
Markova,
Sfacteria,
Fiordaliso,
Grasso,
Sperling,
Kozlov,
Abramov,
Knerlich,
Smart,
Brines,
Latini,
Gomez,
Pobre,
Jacob,
Woldt,
Hand,
Ehrenreich,
Poveshchenko,
Arcasoy,
Ghezzi,
Cerami,
von Ahsen,
Karayal,
- VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Tam, B.Y., Wei, K., Rudge, J.S., Hoffman, J., Holash, J., Park, S.K., Yuan, J., Hefner, C., Chartier, C., Lee, J.S., Jiang, S., Niyak, N.R., Kuypers, F.A., Ma, L., Sundram, U., Wu, G., Garcia, J.A., Schrier, S.L., Maher, J.J., Johnson, R.S., Yancopoulos, G.D., Mulligan, R.C., Kuo, C.J. Nat. Med. (2006)
- Activation of the Jun N-terminal kinase pathway by friend spleen focus-forming virus and its role in the growth and survival of friend virus-induced erythroleukemia cells. Nishigaki, K., Hanson, C., Thompson, D., Yugawa, T., Ruscetti, S. J. Virol. (2005)
- Zidovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murine bone marrow cells. Chitnis, S., Mondal, D., Agrawal, K.C. Life Sci. (2002)
- Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. Kilic, E., Kilic, U., Soliz, J., Bassetti, C.L., Gassmann, M., Hermann, D.M. FASEB J. (2005)
- Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia. Urao, N., Okigaki, M., Yamada, H., Aadachi, Y., Matsuno, K., Matsui, A., Matsunaga, S., Tateishi, K., Nomura, T., Takahashi, T., Tatsumi, T., Matsubara, H. Circ. Res. (2006)
- Erythropoietin deficiency decreases vascular stability in mice. Chen, J., Connor, K.M., Aderman, C.M., Smith, L.E. J. Clin. Invest. (2008)
- Cytokine gene expression in cerebral hemispheres and behavioral reactions of (CBAxC57Bl)F1 mice. Poveshchenko, A.F., Markova, E.V., Korotkova, N.A., Yakushenko, E.V., Abramov, V.V., Kozlov, V.A. Bull. Exp. Biol. Med. (2002)
- Effects of epoetin alfa on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant chemotherapy. O'Shaughnessy, J.A. Clin. Breast Cancer (2002)
- Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Tamura, K., Sudo, T., Senftleben, U., Dadak, A.M., Johnson, R., Karin, M. Cell (2000)
- Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Socolovsky, M., Fallon, A.E., Wang, S., Brugnara, C., Lodish, H.F. Cell (1999)
- SOCS3 is essential in the regulation of fetal liver erythropoiesis. Marine, J.C., McKay, C., Wang, D., Topham, D.J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., Ihle, J.N. Cell (1999)
- Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Digicaylioglu, M., Bichet, S., Marti, H.H., Wenger, R.H., Rivas, L.A., Bauer, C., Gassmann, M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor. Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y., Lodish, H.F. J. Biol. Chem. (1992)
- Interferon-gamma mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo. Thawani, N., Tam, M., Chang, K.H., Stevenson, M.M. Exp. Hematol. (2006)
- Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. Arcasoy, M.O., Karayal, A.F. Biochim. Biophys. Acta (2005)
- Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Choi, H., Chun, Y.S., Kim, S.W., Kim, M.S., Park, J.W. Mol. Pharmacol. (2006)
- Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Quelle, F.W., Wang, J., Feng, J., Wang, D., Cleveland, J.L., Ihle, J.N., Zambetti, G.P. Genes Dev. (1998)
- Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Schmitt, R.M., Bruyns, E., Snodgrass, H.R. Genes Dev. (1991)
- HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. Morita, M., Ohneda, O., Yamashita, T., Takahashi, S., Suzuki, N., Nakajima, O., Kawauchi, S., Ema, M., Shibahara, S., Udono, T., Tomita, K., Tamai, M., Sogawa, K., Yamamoto, M., Fujii-Kuriyama, Y. EMBO J. (2003)
- Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Tauchi, T., Damen, J.E., Toyama, K., Feng, G.S., Broxmeyer, H.E., Krystal, G. Blood (1996)
- Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. Migliaccio, G., Migliaccio, A.R., Kreider, B.L., Rovera, G., Adamson, J.W. J. Cell Biol. (1989)
- Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth. Pharr, P.N., Hankins, D., Hofbauer, A., Lodish, H.F., Longmore, G.D. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor. Brines, M., Grasso, G., Fiordaliso, F., Sfacteria, A., Ghezzi, P., Fratelli, M., Latini, R., Xie, Q.W., Smart, J., Su-Rick, C.J., Pobre, E., Diaz, D., Gomez, D., Hand, C., Coleman, T., Cerami, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells. Rusten, L.S., Dybedal, I., Blomhoff, H.K., Blomhoff, R., Smeland, E.B., Jacobsen, S.E. Blood (1996)
- Erythropoietin receptor signal transduction requires protein geranylgeranylation. Hamadmad, S.N., Henry, M.K., Hohl, R.J. J. Pharmacol. Exp. Ther. (2006)
- Erythropoietin increases the radioresistance of a clonal hematopoietic progenitor cell line expressing a transgene for the erythropoietin receptor. Santucci, M.A., Pierce, J.H., Zannini, S., Fortuna, A., Frezza, G., Babini, L., Rosenstein, M.M., Greenberger, J.S. Stem Cells (1994)
- Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death. Signore, A.P., Weng, Z., Hastings, T., Van Laar, A.D., Liang, Q., Lee, Y.J., Chen, J. J. Neurochem. (2006)
- In vivo effects of the immunosuppressant 15-deoxyspergualin on hematopoiesis in murine allogeneic bone marrow chimeras. Its thrombopoietic activity and reversal of adverse effects with granulocyte colony-stimulating factor and/or erythropoietin. Imamura, M., Han, M., Hashino, S., Kobayashi, H., Imai, K., Kobayashi, S., Tanaka, J., Zhu, X., Kobayashi, M., Fujii, Y. Transplantation (1994)
- Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin. Beckman, D.L., Lin, L.L., Quinones, M.E., Longmore, G.D. Blood (1999)
- Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells. Ryan, J.J., Huang, H., McReynolds, L.J., Shelburne, C., Hu-Li, J., Huff, T.F., Paul, W.E. Exp. Hematol. (1997)
- Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation. Calvo, V., Wood, M., Gjertson, C., Vik, T., Bierer, B.E. Eur. J. Immunol. (1994)
- Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Finkelstein, L.D., Ney, P.A., Liu, Q.P., Paulson, R.F., Correll, P.H. Oncogene (2002)
- Erythropoietin causes down regulation of colony-stimulating factor (CSF-1) receptors on peritoneal exudate macrophages of the mouse. Van Zant, G., Chen, B.D. J. Cell Biol. (1983)
- Disrupted signaling in a mutant J2E cell line that shows enhanced viability, but does not proliferate or differentiate, with erythropoietin. Tilbrook, P.A., Bittorf, T., Busfield, S.J., Chappell, D., Klinken, S.P. J. Biol. Chem. (1996)
- Constitutive activation of Stat-related DNA-binding proteins in erythroid cells by the Friend spleen focus-forming virus. Ohashi, T., Masuda, M., Ruscetti, S.K. Leukemia (1997)
- Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. Miura, O., Nakamura, N., Quelle, F.W., Witthuhn, B.A., Ihle, J.N., Aoki, N. Blood (1994)
- Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Tong, W., Zhang, J., Lodish, H.F. Blood (2005)
- Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines. Silva, M., Benito, A., Sanz, C., Prosper, F., Ekhterae, D., Nuñez, G., Fernandez-Luna, J.L. J. Biol. Chem. (1999)
- CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. Nosaka, Y., Arai, A., Miyasaka, N., Miura, O. J. Biol. Chem. (1999)
- A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Hara, T., Miyajima, A. EMBO J. (1995)
- A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Ehrenreich, H., Hasselblatt, M., Knerlich, F., von Ahsen, N., Jacob, S., Sperling, S., Woldt, H., Vehmeyer, K., Nave, K.A., Sirén, A.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The death-promoting activity of p53 can be inhibited by distinct signaling pathways. Lin, Y., Brown, L., Hedley, D.W., Barber, D.L., Benchimol, S. Blood (2002)
- Effect of anemia and renal cytokine production on erythropoietin production during blood-stage malaria. Chang, K.H., Stevenson, M.M. Kidney Int. (2004)
- Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. Kilic, U., Kilic, E., Soliz, J., Bassetti, C.I., Gassmann, M., Hermann, D.M. FASEB J. (2005)