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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism.

In the cyanobacterium Synechococcus elongatus (PCC 7942) the proteins KaiA, KaiB, and KaiC are required for circadian clock function. We deduced a circadian clock function for KaiA from a combination of biochemical and structural data. Both KaiA and its isolated carboxyl-terminal domain (KaiA180C) stimulated KaiC autophosphorylation and facilitated attenuation of KaiC autophosphorylation by KaiB. An amino-terminal domain (KaiA135N) had no function in the autophosphorylation assay. NMR structure determination showed that KaiA135N is a pseudo-receiver domain. We propose that this pseudo-receiver is a timing input-device that regulates KaiA stimulation of KaiC autophosphorylation, which in turn is essential for circadian timekeeping.[1]

References

  1. Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism. Williams, S.B., Vakonakis, I., Golden, S.S., LiWang, A.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
 
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