The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

kaiA  -  circadian clock protein

Synechococcus sp. WH 8102

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of kaiA

  • Both regulated expression of the clock genes kaiA, kaiB, and kaiC and interactions among the Kai proteins are proposed to be important for circadian function in the cyanobacterium Synechococcus sp. strain PCC 7942 [1].
  • The oscillator of cyanobacteria comprises the products of three kai genes (kaiA, kaiB, and kaiC) [2].
  • To allow continuous monitoring of the circadian clock in cyanobacteria, we previously created a reporter strain (AMC149) of Synechococcus sp. strain PCC 7942 in which the promoter of the psbAI gene was fused to Vibrio harveyi luciferase structural genes (luxAB) and integrated into the chromosome [3].
 

High impact information on kaiA

 

Biological context of kaiA

 

Anatomical context of kaiA

 

Other interactions of kaiA

 

Analytical, diagnostic and therapeutic context of kaiA

  • Electrophoresis mobility shift assay using a 25-base pair complementary oligonucleotide incorporating the kaiA upstream sequence demonstrates that Pex has an affinity for the double-stranded DNA [2].

References

  1. A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria. Iwasaki, H., Williams, S.B., Kitayama, Y., Ishiura, M., Golden, S.S., Kondo, T. Cell (2000) [Pubmed]
  2. Structural and Biochemical Characterization of a Cyanobacterium Circadian Clock-modifier Protein. Arita, K., Hashimoto, H., Igari, K., Akaboshi, M., Kutsuna, S., Sato, M., Shimizu, T. J. Biol. Chem. (2007) [Pubmed]
  3. Bacterial luciferase as a reporter of circadian gene expression in cyanobacteria. Liu, Y., Golden, S.S., Kondo, T., Ishiura, M., Johnson, C.H. J. Bacteriol. (1995) [Pubmed]
  4. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Ishiura, M., Kutsuna, S., Aoki, S., Iwasaki, H., Andersson, C.R., Tanabe, A., Golden, S.S., Johnson, C.H., Kondo, T. Science (1998) [Pubmed]
  5. A cyanobacterial circadian timing mechanism. Ditty, J.L., Williams, S.B., Golden, S.S. Annu. Rev. Genet. (2003) [Pubmed]
  6. Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods. Pattanayek, R., Williams, D.R., Pattanayek, S., Xu, Y., Mori, T., Johnson, C.H., Stewart, P.L., Egli, M. EMBO J. (2006) [Pubmed]
  7. Circadian rhythms in gene transcription imparted by chromosome compaction in the cyanobacterium Synechococcus elongatus. Smith, R.M., Williams, S.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock. Ivleva, N.B., Gao, T., Liwang, A.C., Golden, S.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Functionally important substructures of circadian clock protein KaiB in a unique tetramer complex. Iwase, R., Imada, K., Hayashi, F., Uzumaki, T., Morishita, M., Onai, K., Furukawa, Y., Namba, K., Ishiura, M. J. Biol. Chem. (2005) [Pubmed]
  10. Transcriptional regulation of the circadian clock operon kaiBC by upstream regions in cyanobacteria. Kutsuna, S., Nakahira, Y., Katayama, M., Ishiura, M., Kondo, T. Mol. Microbiol. (2005) [Pubmed]
  11. Roles for sigma factors in global circadian regulation of the cyanobacterial genome. Nair, U., Ditty, J.L., Min, H., Golden, S.S. J. Bacteriol. (2002) [Pubmed]
  12. Independence of circadian timing from cell division in cyanobacteria. Mori, T., Johnson, C.H. J. Bacteriol. (2001) [Pubmed]
  13. Expression of the circadian clock-related gene pex in cyanobacteria increases in darkness and is required to delay the clock. Takai, N., Ikeuchi, S., Manabe, K., Kutsuna, S. J. Biol. Rhythms (2006) [Pubmed]
  14. A novel mutation in kaiC affects resetting of the cyanobacterial circadian clock. Kiyohara, Y.B., Katayama, M., Kondo, T. J. Bacteriol. (2005) [Pubmed]
  15. A period-extender gene, pex, that extends the period of the circadian clock in the cyanobacterium Synechococcus sp. strain PCC 7942. Kutsuna, S., Kondo, T., Aoki, S., Ishiura, M. J. Bacteriol. (1998) [Pubmed]
 
WikiGenes - Universities