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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians.

Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.[1]

References

  1. Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians. Ifergan, I., Bernard, N.F., Bruneau, J., Alary, M., Tsoukas, C.M., Roger, M. AIDS (2002) [Pubmed]
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