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Disease relevance of Permissiveness


Psychiatry related information on Permissiveness

  • The difference in mean response time between pre- and post-HCG tests was significantly different for both the receptivity and permissiveness tests among the five doses [6].
  • To this end, seven themes were isolated from the interview scripts, these being permissiveness, double standards, belief about sexual control (the Id Factor), romance, regrets about permissiveness, sexual aggression, and questioning [7].

High impact information on Permissiveness

  • Three transformed lines (COS-1, -3, -7) were established and found to contain T antigen; retain complete permissiveness for lytic growth of SV40; support the replication of tsA209 virus at 40 degrees C; and support the replication of pure populations of SV40 mutants with deletions in the early region [8].
  • The coexpression of multiple chemokine receptors offers a molecular mechanism to explain the permissiveness of DC for both M- and T-tropic viruses [9].
  • A high viral DNA synthesis and maturation was observed in MVMi-infected myeloid cells, but it was undetectable in MVMp infections; moreover, the expression of the cytotoxic nonstructural NS-1 protein, a more reliable parameter of cell permissiveness to MVM infection, was only detected in MVMi-infected cells [10].
  • Permissiveness to Moloney Murine Leukemia Virus (MoMuLV) expression was examined during preimplantation and early postimplantation development of the mouse embryo [11].
  • This finding suggests that in the double TG mouse model mDCs once infected facilitate systemic MV spreading and infection, which depend on mDC MV permissiveness determined by the level of type I IFN generated via IFNAR1 [12].

Chemical compound and disease context of Permissiveness


Biological context of Permissiveness


Anatomical context of Permissiveness


Gene context of Permissiveness

  • The molecular complex involving CD46 may confer high MV permissiveness leading to immune modulation in Mphi [28].
  • A correlation between binding to CD81 and species permissiveness to HCV infection has also been reported [13].
  • RESULTS: All constructed cell lines expressing the various CXCR4 glycomutants showed similar permissiveness for the X4-monotropic virus and no change in the coreceptor specificity that allows infection of a CCR5-dependent R5-monotropic virus [29].
  • KSHV target cell permissiveness correlated closely with endogenous expression of xCT messenger RNA and protein in diverse human and nonhuman cell types [30].
  • In contrast, cells expressing B27 with the single substitution of F for H at position 9 (B27.H9F) retained their permissiveness [31].

Analytical, diagnostic and therapeutic context of Permissiveness

  • Polymerase chain reaction experiments demonstrate that the two functional variable gene segments (V delta and V alpha/delta) are expressed individually with both C alpha and C delta genes as mRNA, indicating a permissiveness in their expression patterns [32].
  • To investigate this difference in permissiveness, HCMV infection of both cell types was studied using in situ hybridisation (ISH) as well as immunocytochemistry to detect viral DNA and viral proteins [33].


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  2. Genomic sequence analysis of the mouse Naip gene array. Endrizzi, M.G., Hadinoto, V., Growney, J.D., Miller, W., Dietrich, W.F. Genome Res. (2000) [Pubmed]
  3. Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells. Chu, J.J., Ng, M.L. J. Biol. Chem. (2004) [Pubmed]
  4. Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians. Ifergan, I., Bernard, N.F., Bruneau, J., Alary, M., Tsoukas, C.M., Roger, M. AIDS (2002) [Pubmed]
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  6. Hormonal state influences aspects of female mate choice in the Túngara Frog (Physalaemus pustulosus). Lynch, K.S., Crews, D., Ryan, M.J., Wilczynski, W. Hormones and behavior. (2006) [Pubmed]
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  8. SV40-transformed simian cells support the replication of early SV40 mutants. Gluzman, Y. Cell (1981) [Pubmed]
  9. Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Ayehunie, S., Garcia-Zepeda, E.A., Hoxie, J.A., Horuk, R., Kupper, T.S., Luster, A.D., Ruprecht, R.M. Blood (1997) [Pubmed]
  10. In vitro myelosuppressive effects of the parvovirus minute virus of mice (MVMi) on hematopoietic stem and committed progenitor cells. Segovia, J.C., Real, A., Bueren, J.A., Almendral, J.M. Blood (1991) [Pubmed]
  11. Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development. Savatier, P., Morgenstern, J., Beddington, R.S. Development (1990) [Pubmed]
  12. Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection. Shingai, M., Inoue, N., Okuno, T., Okabe, M., Akazawa, T., Miyamoto, Y., Ayata, M., Honda, K., Kurita-Taniguchi, M., Matsumoto, M., Ogura, H., Taniguchi, T., Seya, T. J. Immunol. (2005) [Pubmed]
  13. Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. Meola, A., Sbardellati, A., Bruni Ercole, B., Cerretani, M., Pezzanera, M., Ceccacci, A., Vitelli, A., Levy, S., Nicosia, A., Traboni, C., McKeating, J., Scarselli, E. J. Virol. (2000) [Pubmed]
  14. Heparan sulfate mediates infection of high-neurovirulence Theiler's viruses. Reddi, H.V., Lipton, H.L. J. Virol. (2002) [Pubmed]
  15. Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells. Kubota, Y., Morita, T., Kusakabe, M., Sakakura, T., Ito, K. Dev. Dyn. (1999) [Pubmed]
  16. Persistent coinfection of T lymphocytes with HTLV-II and HIV and the role of syncytium formation in HIV-induced cytopathic effect. Montefiori, D.C., Mitchell, W.M. Virology (1987) [Pubmed]
  17. Butyrate-induced reversal of herpes simplex virus restriction in neuroblastoma cells. Ash, R.J. Virology (1986) [Pubmed]
  18. MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. Bleiber, G., May, M., Suarez, C., Martinez, R., Marzolini, C., Egger, M., Telenti, A. J. Infect. Dis. (2004) [Pubmed]
  19. The kinetics of human immunodeficiency virus reverse transcription are slower in primary human macrophages than in a lymphoid cell line. Collin, M., Gordon, S. Virology (1994) [Pubmed]
  20. Mutation of host cell determinants which discriminate between lytic and persistent mouse hepatitis virus infection results in a fusion-resistant phenotype. Daya, M., Wong, F., Cervin, M., Evans, G., Vennema, H., Spaan, W., Anderson, R. J. Gen. Virol. (1989) [Pubmed]
  21. Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53. Löber, C., Lenz-Stöppler, C., Dobbelstein, M. J. Gen. Virol. (2002) [Pubmed]
  22. Transformation of established murine fibroblasts with an activated cellular Harvey-ras oncogene or the polyoma virus middle T gene increases cell permissiveness to parvovirus minute-virus-of-mice. Mousset, S., Cornelis, J., Spruyt, N., Rommelaere, J. Biochimie (1986) [Pubmed]
  23. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright, E.K., Goodart, S.A., Growney, J.D., Hadinoto, V., Endrizzi, M.G., Long, E.M., Sadigh, K., Abney, A.L., Bernstein-Hanley, I., Dietrich, W.F. Curr. Biol. (2003) [Pubmed]
  24. Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection. Ciuffi, A., Bleiber, G., Muñoz, M., Martinez, R., Loeuillet, C., Rehr, M., Fischer, M., Günthard, H.F., Oxenius, A., Meylan, P., Bonhoeffer, S., Trono, D., Telenti, A. J. Virol. (2004) [Pubmed]
  25. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. Malim, M.H., McCarn, D.F., Tiley, L.S., Cullen, B.R. J. Virol. (1991) [Pubmed]
  26. Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses. Shafti-Keramat, S., Handisurya, A., Kriehuber, E., Meneguzzi, G., Slupetzky, K., Kirnbauer, R. J. Virol. (2003) [Pubmed]
  27. Characterization of an intestinal epithelial cell receptor recognized by the Cryptosporidium parvum sporozoite ligand CSL. Langer, R.C., Schaefer, D.A., Riggs, M.W. Infect. Immun. (2001) [Pubmed]
  28. Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Kurita-Taniguchi, M., Hazeki, K., Murabayashi, N., Fukui, A., Tsuji, S., Matsumoto, M., Toyoshima, K., Seya, T. Mol. Immunol. (2002) [Pubmed]
  29. Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1. Thordsen, I., Polzer, S., Schreiber, M. BMC Infect. Dis. (2002) [Pubmed]
  30. Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT. Kaleeba, J.A., Berger, E.A. Science (2006) [Pubmed]
  31. Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Penttinen, M.A., Heiskanen, K.M., Mohapatra, R., DeLay, M.L., Colbert, R.A., Sistonen, L., Granfors, K. Arthritis Rheum. (2004) [Pubmed]
  32. Organization, sequence, and function of 34.5 kb of genomic DNA encompassing several murine T-cell receptor alpha/delta variable gene segments. Seto, D., Koop, B.F., Deshpande, P., Howard, S., Seto, J., Wilk, E., Wang, K., Hood, L. Genomics (1994) [Pubmed]
  33. Nuclear import as a barrier to infection of human umbilical vein endothelial cells by human cytomegalovirus strain AD169. Slobbe-van Drunen, M.E., Hendrickx, A.T., Vossen, R.C., Speel, E.J., van Dam-Mieras, M.C., Bruggeman, C.A. Virus Res. (1998) [Pubmed]
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