Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Blumenthal, R.D. et al.

Blumenthal, Taylor, Goldman, Brown, Goldenberg,

Abnormal expression of the angiopoietins and Tie receptors in menorrhagic endometrium.

OBJECTIVE: To identify changes in expression of stimulatory and inhibitory factors when normal endometrium becomes menorrhagic. DESIGN: Retrospective blinded immunohistologic study. SETTING: Private research center. PATIENTS: Premenopausal and postmenopausal women with non-menorrhagic and menorrhagic endometrium undergoing curettage or hysterectomy were selected. INTERVENTION(S): Samples of endometrium were obtained from all patients. MAIN OUTCOME MEASURE(S): Expression of angiopoietins 1 and 2, and vascular receptors Tie-1 and Tie-2 and endothelial nitric oxide synthase (eNOS). RESULT(S): Angiopoietin 1 ( ANG-1) expression was similar in non-menorrhagic and menorrhagic endometrium. However, there was a significant increase in expression of ANG-2 and its receptor Tie-2 in menorrhagic tissues, which may be important in destabilizing the endometrial vasculature. Tie-1, responsible for endothelial integrity, was also increased in menorrhagic tissues, and is a likely compensatory mechanism for the existing vascular pathology. Expression of eNOS was also increased in menorrhagic women. CONCLUSION(S): Differences in the expression of ANG-2, Tie-2, Tie-1, and eNOS were found in menorrhagic endometrium, which may represent a new target for therapeutic intervention to correct menorrhagic conditions.[1]

References

Abnormal expression of the angiopoietins and Tie receptors in menorrhagic endometrium. Blumenthal, R.D., Taylor, A.P., Goldman, L., Brown, G., Goldenberg, D.M. Fertil. Steril. (2002) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.