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MeSH Review


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Disease relevance of Hysterectomy


Psychiatry related information on Hysterectomy


High impact information on Hysterectomy

  • Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma [10].
  • PARTICIPANTS: Of 11742 randomly selected women, 8554 nonpregnant, sexually active women without hysterectomies underwent initial HPV DNA testing using the original Hybrid Capture Tube test; a stratified subsample of 1119 specimens was retested using the more analytically sensitive second generation assay, the Hybrid Capture II test [11].
  • PATIENTS: Of 1299 women interviewed prior to hysterectomy, 1101 (84.8%) completed the study and provided information about their sexual functioning [12].
  • Tubal ligation, hysterectomy, and risk of ovarian cancer [13].
  • The risk of death in estrogen users, irrespective of hysterectomy status, was 0.37 times that in nonusers (3.4/1,000 v 9.3/1,000) [14].

Chemical compound and disease context of Hysterectomy


Biological context of Hysterectomy


Anatomical context of Hysterectomy


Associations of Hysterectomy with chemical compounds


Gene context of Hysterectomy

  • The TA repeat at the 5' end of the ER gene was associated with total body calcium (p < 0.05) after adjusting for BMI, oophorectomy and hysterectomy, and OC use [33].
  • Immunohistochemical study indicated that the PR status on preoperative biopsy specimens and hysterectomy specimens was in good agreement, but p53 status was not [34].
  • METHODS: The expression of VEGF and PD-ECGF was evaluated by immunohistochemical staining of tumor specimens from 73 patients with stage Ib-IIb cervical cancer (51, squamous cell carcinoma; 19, adenocarcinoma; 3, adenosquamous carcinoma) who underwent radical hysterectomy [35].
  • For ER beta, ERT but not the status of hysterectomy was associated with higher receptor density [36].
  • CYP1B1 expression appeared to be extremely low in a woman in the secretory stage of the menstrual phase, relative to the ENDO of the other patients who were all in the proliferative stage at hysterectomy [37].

Analytical, diagnostic and therapeutic context of Hysterectomy


  1. Tubal ligation, hysterectomy, and risk of ovarian cancer. Myers, E.R. JAMA (1994) [Pubmed]
  2. Quality of life and cost-effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: a randomised trial. Hurskainen, R., Teperi, J., Rissanen, P., Aalto, A.M., Grenman, S., Kivelä, A., Kujansuu, E., Vuorma, S., Yliskoski, M., Paavonen, J. Lancet (2001) [Pubmed]
  3. Randomised clinical trial of perioperative cefazolin in preventing infection after hysterectomy. Polk, B.F., Tager, I.B., Shapiro, M., Goren-White, B., Goldstein, P., Schoenbaum, S.C. Lancet (1980) [Pubmed]
  4. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Birdsall, M.A., Farquhar, C.M., White, H.D. Ann. Intern. Med. (1997) [Pubmed]
  5. Risk-benefit profile for raloxifene: 4-year data From the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Barrett-Connor, E., Cauley, J.A., Kulkarni, P.M., Sashegyi, A., Cox, D.A., Geiger, M.J. J. Bone Miner. Res. (2004) [Pubmed]
  6. A randomized, double-blind, placebo-controlled, cross-over trial to assess the side effects of medroxyprogesterone acetate in hormone replacement therapy. Kirkham, C., Hahn, P.M., Van Vugt, D.A., Carmichael, J.A., Reid, R.L. Obstetrics and gynecology. (1991) [Pubmed]
  7. Validation of dental panoramic radiography measures for identifying postmenopausal women with spinal osteoporosis. Taguchi, A., Suei, Y., Sanada, M., Ohtsuka, M., Nakamoto, T., Sumida, H., Ohama, K., Tanimoto, K. AJR. American journal of roentgenology. (2004) [Pubmed]
  8. Lack of influence of hysterectomy on meal size and meal number in Fischer-344 rats. Varma, M., Meguid, M.M., Hammond, W.G., Gleason, J.R. Physiol. Behav. (1999) [Pubmed]
  9. Hysterectomy-induced maternal behavior during pregnancy in the rat. Rosenblatt, J.S., Siegel, H.I. Journal of comparative and physiological psychology. (1975) [Pubmed]
  10. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. Keys, H.M., Bundy, B.N., Stehman, F.B., Muderspach, L.I., Chafe, W.E., Suggs, C.L., Walker, J.L., Gersell, D. N. Engl. J. Med. (1999) [Pubmed]
  11. HPV DNA testing in cervical cancer screening: results from women in a high-risk province of Costa Rica. Schiffman, M., Herrero, R., Hildesheim, A., Sherman, M.E., Bratti, M., Wacholder, S., Alfaro, M., Hutchinson, M., Morales, J., Greenberg, M.D., Lorincz, A.T. JAMA (2000) [Pubmed]
  12. Hysterectomy and sexual functioning. Rhodes, J.C., Kjerulff, K.H., Langenberg, P.W., Guzinski, G.M. JAMA (1999) [Pubmed]
  13. Tubal ligation, hysterectomy, and risk of ovarian cancer. Silver, A.L. JAMA (1994) [Pubmed]
  14. Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program Follow-Up Study. Bush, T.L., Cowan, L.D., Barrett-Connor, E., Criqui, M.H., Karon, J.M., Wallace, R.B., Tyroler, H.A., Rifkind, B.M. JAMA (1983) [Pubmed]
  15. Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate). Mizutani, T., Sugihara, A., Nakamuro, K., Terada, N. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  16. Sufentanil does not preempt pain after abdominal hysterectomy. Sarantopoulos, C., Fassoulaki, A. Pain (1996) [Pubmed]
  17. Increased risk of renal cell carcinoma subsequent to hysterectomy. Gago-Dominguez, M., Castelao, J.E., Yuan, J.M., Ross, R.K., Yu, M.C. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
  18. Substance P (Neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures. Gesztesi, Z., Scuderi, P.E., White, P.F., Wright, W., Wender, R.H., D'Angelo, R., Black, L.S., Dalby, P.L., MacLean, D. Anesthesiology (2000) [Pubmed]
  19. Endometrial carcinoma risks among menopausal estrogen plus progestin and unopposed estrogen users in a cohort of postmenopausal women. Lacey, J.V., Brinton, L.A., Lubin, J.H., Sherman, M.E., Schatzkin, A., Schairer, C. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  20. Toward removing uterine fibroids without surgery: subcutaneous infusion of a luteinizing hormone-releasing hormone agonist commencing in the luteal phase. Healy, D.L., Lawson, S.R., Abbott, M., Baird, D.T., Fraser, H.M. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  21. Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy. Ito, K., Hayasaki, M., Tamaya, T. Antimicrob. Agents Chemother. (1990) [Pubmed]
  22. Aromatase cytochrome P450 and cholesterol side-chain cleavage cytochrome P450 in corpora lutea of pregnant rats: diverse regulation by peptide and steroid hormones. Hickey, G.J., Oonk, R.B., Hall, P.F., Richards, J.S. Endocrinology (1989) [Pubmed]
  23. Effect of standard and low-molecular weight heparin fractions on fibrinolysis and platelet aggregation in patients undergoing hysterectomy. Bounameaux, H., Lijnen, H.R., Hellemans, H., Verstraete, M. Thromb. Haemost. (1986) [Pubmed]
  24. Distinct expression of gelatinase A [matrix metalloproteinase (MMP)-2], collagenase-3 (MMP-13), membrane type MMP 1 (MMP-14), and tissue inhibitor of MMPs type 1 mediated by physiological signals during formation and regression of the rat corpus luteum. Liu, K., Olofsson, J.I., Wahlberg, P., Ny, T. Endocrinology (1999) [Pubmed]
  25. Possible role of ovarian epithelial inflammation in ovarian cancer. Ness, R.B., Cottreau, C. J. Natl. Cancer Inst. (1999) [Pubmed]
  26. Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Tibbetts, T.A., DeMayo, F., Rich, S., Conneely, O.M., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  27. Lack of genotoxicity of tamoxifen in human endometrium. Carmichael, P.L., Ugwumadu, A.H., Neven, P., Hewer, A.J., Poon, G.K., Phillips, D.H. Cancer Res. (1996) [Pubmed]
  28. Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. Massey, W.A., Guo, C.B., Dvorak, A.M., Hubbard, W.C., Bhagavan, B.S., Cohan, V.L., Warner, J.A., Kagey-Sobotka, A., Lichtenstein, L.M. J. Immunol. (1991) [Pubmed]
  29. Hysterectomy-induced alterations in prolactin secretion of lactating rats. Kanyicska, B., Nguyen, D.N., Arey, B.J., Freeman, M.E. Endocrinology (1990) [Pubmed]
  30. Benefit-cost analysis of antimicrobial prophylaxis in abdominal and vaginal hysterectomy. Shapiro, M., Schoenbaum, S.C., Tager, I.B., Muñoz, A., Polk, B.F. JAMA (1983) [Pubmed]
  31. Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk women. Veronesi, U., Maisonneuve, P., Rotmensz, N., Costa, A., Sacchini, V., Travaglini, R., D'Aiuto, G., Lovison, F., Gucciardo, G., Muraca, M.G., Pizzichetta, M.A., Conforti, S., Decensi, A., Robertson, C., Boyle, P. J. Natl. Cancer Inst. (2003) [Pubmed]
  32. Prevention of postoperative lymphopenia and granulocytosis by epidural analgesia. Rem, J., Brandt, M.R., Kehlet, H. Lancet (1980) [Pubmed]
  33. Genetic markers, bone mineral density, and serum osteocalcin levels. Sowers, M., Willing, M., Burns, T., Deschenes, S., Hollis, B., Crutchfield, M., Jannausch, M. J. Bone Miner. Res. (1999) [Pubmed]
  34. Prognostic significance of progesterone receptor immunohistochemistry for lymph node metastases in endometrial carcinoma. Iwai, K., Fukuda, K., Hachisuga, T., Mori, M., Uchiyama, M., Iwasaka, T., Sugimori, H. Gynecol. Oncol. (1999) [Pubmed]
  35. Different angiogenic pathways in human cervical cancers. Tokumo, K., Kodama, J., Seki, N., Nakanishi, Y., Miyagi, Y., Kamimura, S., Yoshinouchi, M., Okuda, H., Kudo, T. Gynecol. Oncol. (1998) [Pubmed]
  36. Estrogen receptors alpha and beta in choroid plexus epithelial cells in Alzheimer's disease. Hong-Goka, B.C., Chang, F.L. Neurosci. Lett. (2004) [Pubmed]
  37. Regiospecific expression of cytochrome P4501A1 and 1B1 in human uterine tissue. Vadlamuri, S.V., Glover, D.D., Turner, T., Sarkar, M.A. Cancer Lett. (1998) [Pubmed]
  38. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. Benedetti-Panici, P., Greggi, S., Colombo, A., Amoroso, M., Smaniotto, D., Giannarelli, D., Amunni, G., Raspagliesi, F., Zola, P., Mangioni, C., Landoni, F. J. Clin. Oncol. (2002) [Pubmed]
  39. Coronary vasomotor reactivity among normotensive African and white American subjects with chest pain. Houghton, J.L., Carr, A.A., Strogatz, D.S., Michel, A.I., Phillip, J.L., Kuhner, P.A., Smith, V.E., Breisblatt, W.M. Am. J. Med. (1997) [Pubmed]
  40. Effect of tamoxifen on measurements of hemostasis in healthy women. Mannucci, P.M., Bettega, D., Chantarangkul, V., Tripodi, A., Sacchini, V., Veronesi, U. Arch. Intern. Med. (1996) [Pubmed]
  41. Role of intraluteal estrogen in the regulation of the rat corpus luteum during pregnancy. Gibori, G., Keyes, P.L. Endocrinology (1978) [Pubmed]
  42. Use of neoadjuvant chemotherapy prior to radical hysterectomy in cervical cancer: monitoring tumour shrinkage and molecular profile on magnetic resonance and assessment of 3-year outcome. deSouza, N.M., Soutter, W.P., Rustin, G., Mahon, M.M., Jones, B., Dina, R., McIndoe, G.A. Br. J. Cancer (2004) [Pubmed]
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