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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endometrium


Psychiatry related information on Endometrium


High impact information on Endometrium

  • The interaction of neurohypophysial oxytocin with oxytocin receptors in the endometrium evokes the secretion of luteolytic pulses of uterine PGF2alpha [8].
  • Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women [9].
  • Regardless of the preparation and dosage of the estrogen and progestin used, wholly or predominantly proliferative endometrium was always associated with bleeding on or before day 10 after the addition of progestin; wholly or predominantly secretory endometrium, or a lack of endometrial tissue, was associated with bleeding on day 11 or later [10].
  • We conclude that many estrogen preparations subject the endometrium to a potent stimulus [11].
  • In the uterus, the increase in wet weight was accompanied by proliferation of the endometrium and induction of progesterone receptor (PgR) and complement component C3 [12].

Chemical compound and disease context of Endometrium


Biological context of Endometrium


Anatomical context of Endometrium


Associations of Endometrium with chemical compounds

  • We conclude that the bleeding pattern reflected the histologic condition of the endometrium and that adjustment of the dosage of progestin so that regular bleeding is induced on or after day 11 may obviate the need for endometrial biopsy [10].
  • Nuclear receptors for both estradiol and progesterone were present in twofold higher concentrations in implantation sites than in nonimplantation regions of the endometrium of 6-day pregnant rats [26].
  • These data indicate that matrix metalloproteinases are expressed in cell-type, tissue, and reproductive cycle-specific patterns, consistent with regulation by steroid hormones, and with specific roles in the complex tissue growth and remodeling processes occurring in the endometrium during the reproductive cycle [27].
  • CONCLUSION: The endometrium and gastrointestinal organs may be target sites for tamoxifen-induced carcinogenesis in humans [28].
  • Mesenchyme-epithelial interactions in human endometrium. Prostaglandin synthesis in separated cell types [23].

Gene context of Endometrium

  • HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium [29].
  • We conclude that placenta and endometrium express the same P450 as is found in fetal liver [19].
  • Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta [19].
  • Our results show that LIF is the only one of these factors expressed at detectable levels in the endometrium of women of proven fertility [30].
  • LEFTY A is identical to ebaf, a cDNA previously identified in a search for genes expressed in human endometrium [31].

Analytical, diagnostic and therapeutic context of Endometrium


  1. Recent and past use of conjugated estrogens in relation to adenocarcinoma of the endometrium. Shapiro, S., Kaufman, D.W., Slone, D., Rosenberg, L., Miettinen, O.S., Stolley, P.D., Rosenshein, N.B., Watring, W.G., Leavitt, T., Knapp, R.C. N. Engl. J. Med. (1980) [Pubmed]
  2. Clinical manifestations and treatment of dysfunctional uterine bleeding. Bayer, S.R., DeCherney, A.H. JAMA (1993) [Pubmed]
  3. The comparative effect on bone density, endometrium, and lipids of continuous hormones as replacement therapy (CHART study). A randomized controlled trial. Speroff, L., Rowan, J., Symons, J., Genant, H., Wilborn, W. JAMA (1996) [Pubmed]
  4. Effects of suramin on in vitro growth of fresh human tumors. Taylor, C.W., Lui, R., Fanta, P., Salmon, S.E. J. Natl. Cancer Inst. (1992) [Pubmed]
  5. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. Lessey, B.A., Damjanovich, L., Coutifaris, C., Castelbaum, A., Albelda, S.M., Buck, C.A. J. Clin. Invest. (1992) [Pubmed]
  6. Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Croxatto, H.B., Salvatierra, A.M., Croxatto, H.D., Fuentealba, B. Hum. Reprod. (1993) [Pubmed]
  7. Endocrine and paracrine correlates of endometrial receptivity to blastocyst implantation in the human. Ghosh, D., Sengupta, J. Indian J. Physiol. Pharmacol. (2004) [Pubmed]
  8. Luteolysis: a neuroendocrine-mediated event. McCracken, J.A., Custer, E.E., Lamsa, J.C. Physiol. Rev. (1999) [Pubmed]
  9. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. Delmas, P.D., Bjarnason, N.H., Mitlak, B.H., Ravoux, A.C., Shah, A.S., Huster, W.J., Draper, M., Christiansen, C. N. Engl. J. Med. (1997) [Pubmed]
  10. A simple method for determining the optimal dosage of progestin in postmenopausal women receiving estrogens. Padwick, M.L., Pryse-Davies, J., Whitehead, M.I. N. Engl. J. Med. (1986) [Pubmed]
  11. Effects of estrogens and progestins on the biochemistry and morphology of the postmenopausal endometrium. Whitehead, M.I., Townsend, P.T., Pryse-Davies, J., Ryder, T.A., King, R.J. N. Engl. J. Med. (1981) [Pubmed]
  12. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Johnson, M.D., Kenney, N., Stoica, A., Hilakivi-Clarke, L., Singh, B., Chepko, G., Clarke, R., Sholler, P.F., Lirio, A.A., Foss, C., Reiter, R., Trock, B., Paik, S., Martin, M.B. Nat. Med. (2003) [Pubmed]
  13. Ultrasonography surveillance of endometrium in breast cancer patients on adjuvant tamoxifen. Ciatto, S., Cecchini, S., Bonardi, R., Grazzini, G. Lancet (1994) [Pubmed]
  14. The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk. Duguay, Y., McGrath, M., Lépine, J., Gagné, J.F., Hankinson, S.E., Colditz, G.A., Hunter, D.J., Plante, M., Têtu, B., Bélanger, A., Guillemette, C., De Vivo, I. Cancer Res. (2004) [Pubmed]
  15. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. Kliman, H.J., Feinberg, R.F., Schwartz, L.B., Feinman, M.A., Lavi, E., Meaddough, E.L. Am. J. Pathol. (1995) [Pubmed]
  16. Extensive homology between the Escherichia coli K-12 SerC(PdxF) aminotransferase and a protein encoded by a progesterone-induced mRNA in rabbit and human endometria. van der Zel, A., Lam, H.M., Winkler, M.E. Nucleic Acids Res. (1989) [Pubmed]
  17. The effect of leupeptin on progestin receptors of human uterine tissues. ElDieb, M.R., Andersen, R.N. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  18. Gatekeeper for endometrium: the PTEN tumor suppressor gene. Ali, I.U. J. Natl. Cancer Inst. (2000) [Pubmed]
  19. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. Schuetz, J.D., Kauma, S., Guzelian, P.S. J. Clin. Invest. (1993) [Pubmed]
  20. 17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. Casey, M.L., MacDonald, P.C., Andersson, S. J. Clin. Invest. (1994) [Pubmed]
  21. Fibronectin and cell shape in vivo: studies on the endometrium during pregnancy. Grinnell, F., Head, J.R., Hoffpauir, J. J. Cell Biol. (1982) [Pubmed]
  22. Estrogen receptors in the nidatory sites of the rat endometrium. Martel, D., Psychoyos, A. Science (1981) [Pubmed]
  23. Mesenchyme-epithelial interactions in human endometrium. Prostaglandin synthesis in separated cell types. Gal, D., Casey, M.L., Johnston, J.M., MacDonald, P.C. J. Clin. Invest. (1982) [Pubmed]
  24. Human decidua is a major source of renin. Shaw, K.J., Do, Y.S., Kjos, S., Anderson, P.W., Shinagawa, T., Dubeau, L., Hsueh, W.A. J. Clin. Invest. (1989) [Pubmed]
  25. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. McLaren, J., Prentice, A., Charnock-Jones, D.S., Millican, S.A., Müller, K.H., Sharkey, A.M., Smith, S.K. J. Clin. Invest. (1996) [Pubmed]
  26. Local effect of the blastocyst on estrogen and progesterone receptors in the rat endometrium. Logeat, F., Sartor, P., Hai, M.T., Milgrom, E. Science (1980) [Pubmed]
  27. Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. Rodgers, W.H., Matrisian, L.M., Giudice, L.C., Dsupin, B., Cannon, P., Svitek, C., Gorstein, F., Osteen, K.G. J. Clin. Invest. (1994) [Pubmed]
  28. Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. Stockholm Breast Cancer Study Group. Rutqvist, L.E., Johansson, H., Signomklao, T., Johansson, U., Fornander, T., Wilking, N. J. Natl. Cancer Inst. (1995) [Pubmed]
  29. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Taylor, H.S., Arici, A., Olive, D., Igarashi, P. J. Clin. Invest. (1998) [Pubmed]
  30. Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation. Cullinan, E.B., Abbondanzo, S.J., Anderson, P.S., Pollard, J.W., Lessey, B.A., Stewart, C.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  31. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Kosaki, K., Bassi, M.T., Kosaki, R., Lewin, M., Belmont, J., Schauer, G., Casey, B. Am. J. Hum. Genet. (1999) [Pubmed]
  32. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. Mutter, G.L., Lin, M.C., Fitzgerald, J.T., Kum, J.B., Baak, J.P., Lees, J.A., Weng, L.P., Eng, C. J. Natl. Cancer Inst. (2000) [Pubmed]
  33. Prostaglandin E and F concentrations in human endometrium after insertion of intrauterine contraceptive device. Hillier, K., Kasonde, J.M. Lancet (1976) [Pubmed]
  34. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Arceci, R.J., Croop, J.M., Horwitz, S.B., Housman, D. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  35. Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Bruner, K.L., Rodgers, W.H., Gold, L.I., Korc, M., Hargrove, J.T., Matrisian, L.M., Osteen, K.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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