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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis.

OBJECTIVES: To determine if a tumour necrosis factor (TNF +489) polymorphism is associated with susceptibility to rheumatoid arthritis (RA). METHODS: Two European populations were studied: 217 controls and 238 patients from the north of England and 145 controls and 179 patients from Spain. HLA-DRB1 and TNF +489 markers were typed using polymerase chain reaction based methods. RESULTS: Strong associations were demonstrated with shared epitope (SE) encoding HLA-DRB1 alleles in the English (OR = 2.9 [2.2-3.9]) and Spanish (OR = 2.3 [1.6-3.3]) populations, however no association was found with TNF +489 alleles. Furthermore carriage of TNF +489A was not associated with the presence of radiological erosions, rheumatoid nodules or rheumatoid factor. CONCLUSION: The role of the TNF locus in the genetic background of RA is unclear, however, our data does not support the previous reported association of the TNF +489A allele with RA susceptibility or severity.[1]


  1. TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis. Low, A.S., Gonzalez-Gay, M.A., Akil, M., Amos, R.S., Bax, D.E., Cannings, C., Hajeer, A., Till, S.H., Winfield, J., Ollier, W.E., Wilson, A.G. Clinical and experimental rheumatology. (2002) [Pubmed]
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