- TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis. Low, A.S., Gonzalez-Gay, M.A., Akil, M., Amos, R.S., Bax, D.E., Cannings, C., Hajeer, A., Till, S.H., Winfield, J., Ollier, W.E., Wilson, A.G. Clinical and experimental rheumatology. (2002)