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MeSH Review

Rheumatoid Nodule

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Disease relevance of Rheumatoid Nodule


High impact information on Rheumatoid Nodule

  • Rheumatoid nodules were highly associated with a heterozygosity for two disease associated HLA-DRB1 alleles [6].
  • Association of the risk allele with RA was not affected by sex, age at disease onset, or the presence of either rheumatoid factor or rheumatoid nodules [7].
  • CONCLUSION: The presence of the HLA-DRB1 SE does not appear to significantly increase the risk of rheumatoid nodules among Caucasian patients with RA [8].
  • Pulmonary rheumatoid nodules in an etanercept-treated patient [9].
  • OBJECTIVE: To determine why methotrexate (MTX) exacerbates rheumatoid nodules in some patients, despite the effective suppression of synovial inflammation [10].

Chemical compound and disease context of Rheumatoid Nodule


Biological context of Rheumatoid Nodule

  • HLA-DRB1 alleles were analysed, including DRB1*04 subtypes and associations of DRB1*04 haplotypes with DQB1*0301 or DQB1*0302 alleles, the age of the patients at disease onset, the presence of rheumatoid factor (RF), joint erosions, and rheumatoid nodules [16].
  • OBJECTIVE: To evaluate morphologically and immunohistochemically the role of IgM rheumatoid factor (RF) immune complexes and complement activation in rheumatoid nodule vascular injury, a typical extraarticular manifestation of rheumatoid arthritis [17].
  • There was a trend toward more compound heterozygous genotypes in the male RA group than in the female RA group (p < 0.1), and male sex was associated with higher frequency of rheumatoid nodules (56 vs 35% for female RA) [18].

Anatomical context of Rheumatoid Nodule


Gene context of Rheumatoid Nodule


Analytical, diagnostic and therapeutic context of Rheumatoid Nodule


  1. Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis. van Gaalen, F.A., Toes, R.E., Ditzel, H.J., Schaller, M., Breedveld, F.C., Verweij, C.L., Huizinga, T.W. Arthritis Rheum. (2004) [Pubmed]
  2. Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome. Tannenbaum, H., Pinkus, G.S., Anderson, L.G., Schur, P.H. Arthritis Rheum. (1975) [Pubmed]
  3. Secondary spontaneous pneumothorax in a patient with pulmonary rheumatoid nodules during treatment with methotrexate. Gotsman, I., Goral, A., Nusair, S. Rheumatology (Oxford, England) (2001) [Pubmed]
  4. Bilateral epibulbar rheumatoid nodulosis. A new ocular entity. Lebowitz, M.A., Jakobiec, F.A., Donnenfeld, E.D., Starr, M. Ophthalmology (1988) [Pubmed]
  5. Chronic active hepatitis presenting with rheumatoid nodules and arthritis. Fitz, J.G., Petri, M., Hellmann, D. J. Rheumatol. (1987) [Pubmed]
  6. Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. Weyand, C.M., Xie, C., Goronzy, J.J. J. Clin. Invest. (1992) [Pubmed]
  7. Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. van Oene, M., Wintle, R.F., Liu, X., Yazdanpanah, M., Gu, X., Newman, B., Kwan, A., Johnson, B., Owen, J., Greer, W., Mosher, D., Maksymowych, W., Keystone, E., Rubin, L.A., Amos, C.I., Siminovitch, K.A. Arthritis Rheum. (2005) [Pubmed]
  8. Lack of association of the HLA-DRB1 shared epitope with rheumatoid nodules: an individual patient data meta-analysis of 3,272 Caucasian patients with rheumatoid arthritis. Gorman, J.D., David-Vaudey, E., Pai, M., Lum, R.F., Criswell, L.A. Arthritis Rheum. (2004) [Pubmed]
  9. Pulmonary rheumatoid nodules in an etanercept-treated patient. Hübscher, O., Re, R., Iotti, R. Arthritis Rheum. (2003) [Pubmed]
  10. Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Merrill, J.T., Shen, C., Schreibman, D., Coffey, D., Zakharenko, O., Fisher, R., Lahita, R.G., Salmon, J., Cronstein, B.N. Arthritis Rheum. (1997) [Pubmed]
  11. Low dose long-term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events. Saag, K.G., Koehnke, R., Caldwell, J.R., Brasington, R., Burmeister, L.F., Zimmerman, B., Kohler, J.A., Furst, D.E. Am. J. Med. (1994) [Pubmed]
  12. Constitutive production of angiotensin converting enzyme from rheumatoid nodule cells under serum free conditions. Goto, M., Sasano, M., Fuzisawa, M., Okabe, T., Nishizawa, K. Ann. Rheum. Dis. (1992) [Pubmed]
  13. Sulphasalazine and regression of rheumatoid nodules. Englert, H.J., Hughes, G.R., Walport, M.J. Ann. Rheum. Dis. (1987) [Pubmed]
  14. Immunological and immunohistochemical analysis of rheumatoid nodules. Miyasaka, N., Sato, K., Yamamoto, K., Goto, M., Nishioka, K. Ann. Rheum. Dis. (1989) [Pubmed]
  15. Palindromic rheumatism with rheumatoid nodules: a case report with ultrastructural studies. Schreiber, S., Schumacher, H.R., Cherian, P.V. Ann. Rheum. Dis. (1986) [Pubmed]
  16. Differences between female and male patients with familial rheumatoid arthritis. Laivoranta-Nyman, S., Luukkainen, R., Hakala, M., Hannonen, P., Möttönen, T., Yli-Kerttula, U., Ilonen, J., Toivanen, A. Ann. Rheum. Dis. (2001) [Pubmed]
  17. Complement mediated vascular endothelial injury in rheumatoid nodules: a histopathological and immunohistochemical study. Kato, H., Yamakawa, M., Ogino, T. J. Rheumatol. (2000) [Pubmed]
  18. HLA-DRB1 genotype influences risk for and severity of rheumatoid arthritis. Meyer, J.M., Evans, T.I., Small, R.E., Redford, T.W., Han, J., Singh, R., Moxley, G. J. Rheumatol. (1999) [Pubmed]
  19. Tumour necrosis factor alpha independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules. Baeten, D., De Keyser, F., Veys, E.M., Theate, Y., Houssiau, F.A., Durez, P. Ann. Rheum. Dis. (2004) [Pubmed]
  20. A combined immunohistological and histochemical analysis of lymphocyte and macrophage subpopulations in the rheumatoid nodule. Duke, O.L., Hobbs, S., Panayi, G.S., Poulter, L.W., Rasker, J.J., Janossy, G. Clin. Exp. Immunol. (1984) [Pubmed]
  21. Dominant T cell receptor rearrangements in interleukin 2 expanded lymphocytes from rheumatoid nodules suggest antigen driven T cell activation in situ. De Keyser, F., Elewaut, D., Overmeer-Graus, J.P., Van den Broek, P., Rijnders, A.W., Veys, E.M. J. Rheumatol. (1997) [Pubmed]
  22. Cells expressing dendritic cell markers are present in the rheumatoid nodule. Highton, J., Kean, A., Hessian, P.A., Thomson, J., Rietveld, J., Hart, D.N. J. Rheumatol. (2000) [Pubmed]
  23. Phenotypic markers of lymphocyte and mononuclear phagocyte activation within rheumatoid nodules. Highton, J., Palmer, D.G., Smith, M., Hessian, P.A. J. Rheumatol. (1990) [Pubmed]
  24. A comparative phenotypical analysis of rheumatoid nodules and rheumatoid synovium with special reference to adhesion molecules and activation markers. Elewaut, D., De Keyser, F., De Wever, N., Baeten, D., Van Damme, N., Verbruggen, G., Cuvelier, C., Veys, E.M. Ann. Rheum. Dis. (1998) [Pubmed]
  25. Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis. Wisłowska, M., Jabłońska, B. Clin. Rheumatol. (2005) [Pubmed]
  26. TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis. Low, A.S., Gonzalez-Gay, M.A., Akil, M., Amos, R.S., Bax, D.E., Cannings, C., Hajeer, A., Till, S.H., Winfield, J., Ollier, W.E., Wilson, A.G. Clinical and experimental rheumatology. (2002) [Pubmed]
  27. Identification and prevalence of rheumatoid nodules in the finger tendons using high frequency ultrasonography. Kotob, H., Kamel, M. J. Rheumatol. (1999) [Pubmed]
  28. Pseudorheumatoid nodules in an adult. Cohen, J.M. The Journal of foot surgery. (1983) [Pubmed]
  29. An ELISA for IgA-IgG and IgM-RF measurement. II. RF in several disease and control groups and under gold therapy in RA. Lemm, G., Ruschen, S., Warnatz, H. Scand. J. Rheumatol. Suppl. (1988) [Pubmed]
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