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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RUNX transcription factors as key targets of TGF-beta superfamily signaling.

The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.[1]

References

  1. RUNX transcription factors as key targets of TGF-beta superfamily signaling. Ito, Y., Miyazono, K. Curr. Opin. Genet. Dev. (2003) [Pubmed]
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