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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome.

A 47-year-old man, who had been diagnosed as myelodysplastic syndrome (MDS), complained of a severe cough and a high-grade fever. Chest CT disclosed scattered small nodules and ground-glass opacities with interlobular septal thickening in both lung fields and a mass lesion in the right lower lobe. Pathological findings of the ground-glass opacities and the mass lesion obtained by video-assisted thoracoscopic surgery revealed the accumulation of eosinophilic amorphous material in the alveoli and confirmed the diagnosis of pulmonary alveolar proteinosis ( PAP). Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in sera were below sensitivity, while the GM-CSF level was elevated in bronchoalveolar lavage fluid. He was diagnosed as secondary PAP associated with MDS.[1]


  1. Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome. Ohnishi, T., Yamada, G., Shijubo, N., Takagi-Takahashi, Y., Itoh, T., Takahashi, H., Satoh, M., Koba, H., Nakata, K., Abe, S. Intern. Med. (2003) [Pubmed]
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