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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients.

Multiple sclerosis ( MS) is an immune-mediate, inflammatory and demyelinating disease of the central nervous system (CNS). Since glutamate (Glu) is a modulator of T lymphocyte function and Glu excitotoxicity has been proposed as one of the mechanisms of the demyelination, we studied the responses of T lymphocytes from normal controls (NC), MS or other non-inflammatory neurological disease (ONND) patients to Glu, by measuring phytohemagglutinin-induced intracellular Ca(2+) ([Ca(2+)](i)) rise (Fura-2 method) and cell proliferation (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide colorimetric assay). No differences in the Glu (1 microM)-induced potentiation of the [Ca(2+)](i) rise were measured in T lymphocytes from all groups of subjects, while a significant decrease in the Glu (1 mM)-induced inhibition of cell proliferation was observed in T lymphocytes from MS patients. These data demonstrate that MS T lymphocytes abnormally respond to Glu.[1]


  1. Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients. Lombardi, G., Miglio, G., Canonico, P.L., Naldi, P., Comi, C., Monaco, F. Neurosci. Lett. (2003) [Pubmed]
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