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MeSH Review

Demyelinating Diseases

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Disease relevance of Demyelinating Diseases


Psychiatry related information on Demyelinating Diseases


High impact information on Demyelinating Diseases

  • We now demonstrate that mice devoid of Pmp22 are retarded in the onset of myelination and develop abundant sausage-like hypermyelination structures (tomacula) at a young age followed by severe demyelination, axonal loss and functional impairment [10].
  • Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy [11].
  • A deletion of MBP sequences in the genome of shiverer mice was also demonstrated. cDNAs for MBP will allow molecular investigation of the role this gene plays in both dysmyelinating and demyelinating diseases, as well as questions of MBP biosynthesis [12].
  • These findings demonstrate that lymphocytic cells reactive to myelin basic protein are present in the spinal fluid during active demyelinating disease; and that these cells may be more reactive than peripheral blood lymphocytes [13].
  • Thus, autoimmune responses to sulfatide and other lipids are present in individuals with multiple sclerosis and in EAE, and may contribute to the pathogenesis of autoimmune demyelination [14].

Chemical compound and disease context of Demyelinating Diseases


Biological context of Demyelinating Diseases


Anatomical context of Demyelinating Diseases


Gene context of Demyelinating Diseases


Analytical, diagnostic and therapeutic context of Demyelinating Diseases


  1. Immunological aspects of demyelinating diseases. Martin, R., McFarland, H.F., McFarlin, D.E. Annu. Rev. Immunol. (1992) [Pubmed]
  2. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Kuokkanen, S., Sundvall, M., Terwilliger, J.D., Tienari, P.J., Wikström, J., Holmdahl, R., Pettersson, U., Peltonen, L. Nat. Genet. (1996) [Pubmed]
  3. A virus-induced molecular mimicry model of multiple sclerosis. Olson, J.K., Croxford, J.L., Calenoff, M.A., Dal Canto, M.C., Miller, S.D. J. Clin. Invest. (2001) [Pubmed]
  4. Cladribine in treatment of chronic progressive multiple sclerosis. Sipe, J.C., Romine, J.S., Koziol, J.A., McMillan, R., Zyroff, J., Beutler, E. Lancet (1994) [Pubmed]
  5. Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy. Shapiro, E., Krivit, W., Lockman, L., Jambaqué, I., Peters, C., Cowan, M., Harris, R., Blanche, S., Bordigoni, P., Loes, D., Ziegler, R., Crittenden, M., Ris, D., Berg, B., Cox, C., Moser, H., Fischer, A., Aubourg, P. Lancet (2000) [Pubmed]
  6. Neuropsychology of multiple sclerosis: a critical review. Rao, S.M. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1986) [Pubmed]
  7. Pathogenetic role of phagocytic abnormalities in human virus immunodeficiency infection: possible therapeutical approaches. A review. Covelli, V., Pece, S., Giuliani, G., De Simone, C., Jirillo, E. Immunopharmacology and immunotoxicology. (1997) [Pubmed]
  8. Auditory deficits in multiple sclerosis: a review. Mustillo, P. Audiology (1984) [Pubmed]
  9. Rho kinase, a promising drug target for neurological disorders. Mueller, B.K., Mack, H., Teusch, N. Nature reviews. Drug discovery. (2005) [Pubmed]
  10. Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Adlkofer, K., Martini, R., Aguzzi, A., Zielasek, J., Toyka, K.V., Suter, U. Nat. Genet. (1995) [Pubmed]
  11. Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Matsushima, G.K., Taniike, M., Glimcher, L.H., Grusby, M.J., Frelinger, J.A., Suzuki, K., Ting, J.P. Cell (1994) [Pubmed]
  12. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Roach, A., Boylan, K., Horvath, S., Prusiner, S.B., Hood, L.E. Cell (1983) [Pubmed]
  13. In vitro cell-mediated immunity of cerebrospinal-fluid lymphocytes to myelin basic protein in primary demyelinating diseases. Lisak, R.P., Zweiman, B. N. Engl. J. Med. (1977) [Pubmed]
  14. Lipid microarrays identify key mediators of autoimmune brain inflammation. Kanter, J.L., Narayana, S., Ho, P.P., Catz, I., Warren, K.G., Sobel, R.A., Steinman, L., Robinson, W.H. Nat. Med. (2006) [Pubmed]
  15. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Liu, J., Marino, M.W., Wong, G., Grail, D., Dunn, A., Bettadapura, J., Slavin, A.J., Old, L., Bernard, C.C. Nat. Med. (1998) [Pubmed]
  16. Glutamate excitotoxicity in a model of multiple sclerosis. Pitt, D., Werner, P., Raine, C.S. Nat. Med. (2000) [Pubmed]
  17. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Arnett, H.A., Mason, J., Marino, M., Suzuki, K., Matsushima, G.K., Ting, J.P. Nat. Neurosci. (2001) [Pubmed]
  18. Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. Diestel, A., Aktas, O., Hackel, D., Hake, I., Meier, S., Raine, C.S., Nitsch, R., Zipp, F., Ullrich, O. J. Exp. Med. (2003) [Pubmed]
  19. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Surtees, R., Leonard, J., Austin, S. Lancet (1991) [Pubmed]
  20. Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Kagawa, T., Ikenaka, K., Inoue, Y., Kuriyama, S., Tsujii, T., Nakao, J., Nakajima, K., Aruga, J., Okano, H., Mikoshiba, K. Neuron (1994) [Pubmed]
  21. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. Akassoglou, K., Kombrinck, K.W., Degen, J.L., Strickland, S. J. Cell Biol. (2000) [Pubmed]
  22. Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. Chamberlin, M.E., Ubagai, T., Mudd, S.H., Thomas, J., Pao, V.Y., Nguyen, T.K., Levy, H.L., Greene, C., Freehauf, C., Chou, J.Y. Am. J. Hum. Genet. (2000) [Pubmed]
  23. Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology. Marta, C.B., Oliver, A.R., Sweet, R.A., Pfeiffer, S.E., Ruddle, N.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  24. Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. von Büdingen, H.C., Hauser, S.L., Fuhrmann, A., Nabavi, C.B., Lee, J.I., Genain, C.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. Harroch, S., Furtado, G.C., Brueck, W., Rosenbluth, J., Lafaille, J., Chao, M., Buxbaum, J.D., Schlessinger, J. Nat. Genet. (2002) [Pubmed]
  26. Increased levels of myelin basic protein transcripts in virus-induced demyelination. Kristensson, K., Holmes, K.V., Duchala, C.S., Zeller, N.K., Lazzarini, R.A., Dubois-Dalcq, M. Nature (1986) [Pubmed]
  27. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. McQualter, J.L., Darwiche, R., Ewing, C., Onuki, M., Kay, T.W., Hamilton, J.A., Reid, H.H., Bernard, C.C. J. Exp. Med. (2001) [Pubmed]
  28. Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients. Su, Y., Brooks, D.G., Li, L., Lepercq, J., Trofatter, J.A., Ravetch, J.V., Lebo, R.V. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  29. Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Komoly, S., Hudson, L.D., Webster, H.D., Bondy, C.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  30. A critical role for lymphotoxin in experimental allergic encephalomyelitis. Suen, W.E., Bergman, C.M., Hjelmström, P., Ruddle, N.H. J. Exp. Med. (1997) [Pubmed]
  31. Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis. Mastronardi, F.G., Mak, B., Ackerley, C.A., Roots, B.I., Moscarello, M.A. J. Clin. Invest. (1996) [Pubmed]
  32. Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy. Pujol, A., Ferrer, I., Camps, C., Metzger, E., Hindelang, C., Callizot, N., Ruiz, M., Pàmpols, T., Giròs, M., Mandel, J.L. Hum. Mol. Genet. (2004) [Pubmed]
  33. Radioimmunoassay of myelin basic protein in spinal fluid. An index of active demyelination. Cohen, S.R., Herndon, R.M., McKhann, G.M. N. Engl. J. Med. (1976) [Pubmed]
  34. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. Genain, C.P., Lee-Parritz, D., Nguyen, M.H., Massacesi, L., Joshi, N., Ferrante, R., Hoffman, K., Moseley, M., Letvin, N.L., Hauser, S.L. J. Clin. Invest. (1994) [Pubmed]
  35. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. Genain, C.P., Nguyen, M.H., Letvin, N.L., Pearl, R., Davis, R.L., Adelman, M., Lees, M.B., Linington, C., Hauser, S.L. J. Clin. Invest. (1995) [Pubmed]
  36. Reactions to iophendylate in relation to multiple sclerosis. Kaufmann, P., Jeans, W.D. Lancet (1976) [Pubmed]
  37. Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gupta, G., Gelfand, J.M., Lewis, J.D. Gastroenterology (2005) [Pubmed]
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