- Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog. Stewart, J.A., Wei, C.C., Brower, G.L., Rynders, P.E., Hankes, G.H., Dillon, A.R., Lucchesi, P.A., Janicki, J.S., Dell'Italia, L.J. J. Mol. Cell. Cardiol. (2003)