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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Piperazine hepatitis.

The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver. The humoral or cellular immune basis for such hypersensitivity has not been elucidated.[1]


  1. Piperazine hepatitis. Hamlyn, A.N., Morris, J.S., Sarkany, I., Sherlock, S. Gastroenterology (1976) [Pubmed]
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