Chemical Compound Review:
Antepan piperazine
Synonyms:
Pipersol, Antiren, Entacyl, Eraverm, Lumbrical, ...
Debnath,
Williams,
Donnelly,
Doss,
Miller,
Zhang,
Teffera,
Nargund,
Palucki,
Park,
Tang,
Evans,
Baillie,
Stearns,
Tagat,
Steensma,
McCombie,
Nazareno,
Lin,
Neustadt,
Cox,
Xu,
Wojcik,
Murray,
Vantuno,
Baroudy,
Strizki,
Vu,
Peng,
Kumaravel,
Smits,
Jin,
Phadke,
Engber,
Huang,
Reilly,
Tam,
Grant,
Hetu,
Chen,
Zhang,
Petter,
Voziyan,
Metz,
Baynes,
Hudson,
- Piperazine hepatitis. Hamlyn, A.N., Morris, J.S., Sarkany, I., Sherlock, S. Gastroenterology (1976)
- Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. Esnouf, R.M., Ren, J., Hopkins, A.L., Ross, C.K., Jones, E.Y., Stammers, D.K., Stuart, D.I. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic efficacy of mebendazole, pyrantel, piperazine, and levamisole. Duncombe, V.M., Bolin, T.D., Davis, A.E., Fagan, M.R., Kelly, J.D. Gut (1979)
- Effect of periodic antiascaris and antigiardia treatment on nutritional status of preschool children. Gupta, M.C., Urrutia, J.J. Am. J. Clin. Nutr. (1982)
- 5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model. Kennett, G.A. Psychopharmacology (Berl.) (1992)
- Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. Lucki, I., Ward, H.R., Frazer, A. J. Pharmacol. Exp. Ther. (1989)
- FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel potential antidementia drug, improves visual recognition memory in rhesus monkeys: comparison with physostigmine. Matsuoka, N., Aigner, T.G. J. Pharmacol. Exp. Ther. (1997)
- Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline. Doss, G.A., Miller, R.R., Zhang, Z., Teffera, Y., Nargund, R.P., Palucki, B., Park, M.K., Tang, Y.S., Evans, D.C., Baillie, T.A., Stearns, R.A. Chem. Res. Toxicol. (2005)
- Individual differences in multiple-bag spindles of cat superficial lumbrical muscles. Decorte, L., Emonet-Dénand, F., Harker, D.W., Laporte, Y. J. Anat. (1990)
- Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor. Gerard, C., McPhail, L.C., Marfat, A., Stimler-Gerard, N.P., Bass, D.A., McCall, C.E. J. Clin. Invest. (1986)
- Nitrosation of piperazine in the stomach. Bellander, B.T., Hagmar, L.E., Osterdahl, B.G. Lancet (1981)
- A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. Demchyshyn, L., Sunahara, R.K., Miller, K., Teitler, M., Hoffman, B.J., Kennedy, J.L., Seeman, P., Van Tol, H.H., Niznik, H.B. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys. Grondin, R., Zhang, Z., Gerhardt, G.A., Gash, D.M. Ann. Neurol. (2000)
- Intracellular distribution of the Wilson's disease gene product (ATPase7B) after in vitro and in vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson's disease. Nagano, K., Nakamura, K., Urakami, K.I., Umeyama, K., Uchiyama, H., Koiwai, K., Hattori, S., Yamamoto, T., Matsuda, I., Endo, F. Hepatology (1998)
- Flunarizine and cinnarizine inhibit mitochondrial complexes I and II: possible implication for parkinsonism. Veitch, K., Hue, L. Mol. Pharmacol. (1994)
- Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14. Oren, D.A., Zhang, A., Nesvadba, H., Rosenwirth, B., Arnold, E. J. Mol. Biol. (1996)
- Ranolazine: a review of its use in chronic stable angina pectoris. Siddiqui, M.A., Keam, S.J. Drugs (2006)
- Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. Najajreh, Y., Perez, J.M., Navarro-Ranninger, C., Gibson, D. J. Med. Chem. (2002)
- Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist. Tagat, J.R., Steensma, R.W., McCombie, S.W., Nazareno, D.V., Lin, S.I., Neustadt, B.R., Cox, K., Xu, S., Wojcik, L., Murray, M.G., Vantuno, N., Baroudy, B.M., Strizki, J.M. J. Med. Chem. (2001)
- Protein kinase inhibitors selectively block phorbol ester- or forskolin-induced changes in excitability of Aplysia neurons. Conn, P.J., Strong, J.A., Azhderian, E.M., Nairn, A.C., Greengard, P., Kaczmarek, L.K. J. Neurosci. (1989)
- Inhibition of human neutrophil chemotaxis by the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine. Harvath, L., McCall, C.E., Bass, D.A., McPhail, L.C. J. Immunol. (1987)
- Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2. Clark, G.R., Squire, C.J., Gray, E.J., Leupin, W., Neidle, S. Nucleic Acids Res. (1996)
- Photoaffinity labeling of the dopamine reuptake carrier protein with 3-azido[3H]GBR-12935. Berger, S.P., Martenson, R.E., Laing, P., Thurkauf, A., Decosta, B., Rice, K.C., Paul, S.M. Mol. Pharmacol. (1991)
- 5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells. Cowen, D.S., Molinoff, P.B., Manning, D.R. Mol. Pharmacol. (1997)
- Formation of primary and secondary myotubes in rat lumbrical muscles. Ross, J.J., Duxson, M.J., Harris, A.J. Development (1987)
- Neural determination of muscle fibre numbers in embryonic rat lumbrical muscles. Ross, J.J., Duxson, M.J., Harris, A.J. Development (1987)
- The effect of selective, chronic stimulation on motor unit size in developing rat muscle. Ridge, R.M., Betz, W.J. J. Neurosci. (1984)
- The origin of secondary myotubes in mammalian skeletal muscles: ultrastructural studies. Duxson, M.J., Usson, Y., Harris, A.J. Development (1989)
- Three serotonin responses in cultured mouse hippocampal and striatal neurons. Yakel, J.L., Trussell, L.O., Jackson, M.B. J. Neurosci. (1988)
- Sprouting of active nerve terminals in partially inactive muscles of the rat. Betz, W.J., Caldwell, J.H., Ribchester, R.R. J. Physiol. (Lond.) (1980)
- Generation of predictive pharmacophore models for CCR5 antagonists: study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors. Debnath, A.K. J. Med. Chem. (2003)
- Interferon-gamma-dependent stimulation of Fas antigen in SV40-transformed human keratinocytes: modulation of the apoptotic process by protein kinase C. Takahashi, H., Kobayashi, H., Hashimoto, Y., Matsuo, S., Iizuka, H. J. Invest. Dermatol. (1995)
- Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats. Delon, A., Bouquet, S., Huguet, F., Brunet, V., Courtois, P., Couet, W. Antimicrob. Agents Chemother. (1999)
- Characterization of inward-rectifier K+ channel inhibition by antiarrhythmic piperazine. Xu, Y., Lu, Z. Biochemistry (2004)
- Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals. Brooke, R.E., Moores, T.S., Morris, N.P., Parson, S.H., Deuchars, J. Eur. J. Neurosci. (2004)
- Gastric mucosal damage following repeat administration of melanocortin subtype-4 receptor ligands to Fischer 344 rats. Williams, T.M., Donnelly, K.B. Toxicologic pathology (2006)
- Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. Vu, C.B., Peng, B., Kumaravel, G., Smits, G., Jin, X., Phadke, D., Engber, T., Huang, C., Reilly, J., Tam, S., Grant, D., Hetu, G., Chen, L., Zhang, J., Petter, R.C. J. Med. Chem. (2004)
- Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a "divide and conquer" strategy. Ambrose Amin, E., Welsh, W.J. J. Med. Chem. (2001)
- A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. Voziyan, P.A., Metz, T.O., Baynes, J.W., Hudson, B.G. J. Biol. Chem. (2002)
- The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study. Rosenwasser, R.H., Tuma, R.F., Buchheit, W.A. Stroke (1986)
- The biological suppression of malaria: an ecological and nutritional interrelationship of a host and two parasites. Murray, J., Murray, A., Murray, M., Murray, C. Am. J. Clin. Nutr. (1978)
- Evidence for active chloride accumulation in normal and denervated rat lumbrical muscle. Harris, G.L., Betz, W.J. J. Gen. Physiol. (1987)
- Lumbrical sparing in carpal tunnel syndrome: anatomic, physiologic, and diagnostic implications. Logigian, E.L., Busis, N.A., Berger, A.R., Bruyninckx, F., Khalil, N., Shahani, B.T., Young, R.R. Neurology (1987)