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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice.

The stimulated expression of the c-fos gene was used in this study to characterize the residual vision of retinal degeneration (rd) mice. Conventional immunohistochemistry was employed to detect Fos-positive nuclei in the rd mouse retina and brain after monocular application of static and dynamic photic stimuli. Diffuse light induced Fos-positive nuclei in the inner nuclear and ganglion cell layers of the stimulated retina and in the contralateral pretectal olivary nucleus. On the other hand, Fos-positive nuclei were rarely detected in the rd mouse retina and brain after stimulation with a slowly displaced random-dot pattern. These results suggest that the residual vision of the rd mouse involves mainly the circuits that are related to the processing of static photic stimuli.[1]

References

  1. Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice. Lima, A.G., Britto, L.R., Hossokawa, N.M., Hamassaki-Britto, D.E. Neurosci. Lett. (2003) [Pubmed]
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