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MeSH Review

Olivary Nucleus

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Disease relevance of Olivary Nucleus

  • Since 3-AP causes both a profound loss of the climbing fiber input to the cerebellum derived from the inferior olivary nucleus, and the degeneration of nigrostriatal dopamine neurons, 3-AP administration may provide a useful model of olivopontocerebellar atrophy-associated parkinsonism [1].
  • Diffuse light induced Fos-positive nuclei in the inner nuclear and ganglion cell layers of the stimulated retina and in the contralateral pretectal olivary nucleus [2].
  • Because SYP is a marker protein for presynaptic vesicles, presynaptic terminals in the inferior olivary nucleus seem to change their distribution during the course of olivary hypertrophy [3].

High impact information on Olivary Nucleus

  • In the brainstem, neurons in the lateral superior olivary nucleus and the anteroventral cochlear nucleus are transiently 5-HT immunolabeled [4].
  • The inferior olivary nucleus contained significant quantities of alpha 2, alpha 4, and gamma 1 transcripts, with the alpha 1, alpha 3, beta 2, beta 3, and gamma 2 mRNAs also present [5].
  • An antiserum directed against the human form of corticotropin-releasing factor (CRF) was utilized for immunohistochemical visualization of the distribution of this peptide in the inferior olivary nucleus and cerebellum of 2 monkey species (Saimiri sciureus, Macaca fascicularis) [6].
  • Following glutaraldehyde fixation, dense immunocytochemical staining was observed in cerebral cortical neurons, some cerebellar granule cells, hippocampal pyramidal cells, and neurons of the inferior olivary nucleus [7].
  • These findings suggest that glycine may be a neurotransmitter mediating binaural inhibition in certain SOC neurons and that the projection to the lateral superior olivary nucleus from the medial nucleus of the trapezoid body may be glycinergic [8].

Biological context of Olivary Nucleus


Anatomical context of Olivary Nucleus


Associations of Olivary Nucleus with chemical compounds


Gene context of Olivary Nucleus


Analytical, diagnostic and therapeutic context of Olivary Nucleus


  1. 3-Acetylpyridine-induced degeneration of the nigrostriatal dopamine system: an animal model of olivopontocerebellar atrophy-associated parkinsonism. Deutch, A.Y., Rosin, D.L., Goldstein, M., Roth, R.H. Exp. Neurol. (1989) [Pubmed]
  2. Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice. Lima, A.G., Britto, L.R., Hossokawa, N.M., Hamassaki-Britto, D.E. Neurosci. Lett. (2003) [Pubmed]
  3. Altered synaptophysin-immunoreactive pattern in human olivary hypertrophy. Kawanami, T., Kato, T., Llena, J.F., Hirano, A., Sasaki, H. Neurosci. Lett. (1994) [Pubmed]
  4. Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. Cases, O., Lebrand, C., Giros, B., Vitalis, T., De Maeyer, E., Caron, M.G., Price, D.J., Gaspar, P., Seif, I. J. Neurosci. (1998) [Pubmed]
  5. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. Laurie, D.J., Seeburg, P.H., Wisden, W. J. Neurosci. (1992) [Pubmed]
  6. Corticotropin-releasing factor in olivocerebellar climbing-fiber system of monkey (Saimiri sciureus and Macaca fascicularis): parasagittal and regional organization visualized by immunohistochemistry. Cha, C.I., Foote, S.L. J. Neurosci. (1988) [Pubmed]
  7. Monoclonal antibodies specific for fixative-modified aspartate: immunocytochemical localization in the rat CNS. Madl, J.E., Beitz, A.J., Johnson, R.L., Larson, A.A. J. Neurosci. (1987) [Pubmed]
  8. Strychnine blocks binaural inhibition in lateral superior olivary neurons. Moore, M.J., Caspary, D.M. J. Neurosci. (1983) [Pubmed]
  9. Neuronal localization of specific angiotensin II binding sites in the rat inferior olivary nucleus. Walters, D.E., Speth, R.C. J. Neurochem. (1988) [Pubmed]
  10. Expression of corticotropin-releasing hormone transgenes in neurons of adult and developing mice. Keegan, C.E., Karolyi, I.J., Knapp, L.T., Bourbonais, F.J., Camper, S.A., Seasholtz, A.F. Mol. Cell. Neurosci. (1994) [Pubmed]
  11. Glycine receptors in the human substantia nigra as defined by [3H]strychnine binding. de Montis, G., Beaumont, K., Javoy-Agid, F., Agid, Y., Constandinidis, J., Lowenthal, A., Lloyd, K.G. J. Neurochem. (1982) [Pubmed]
  12. Regional cerebral glucose utilization rates in rats during asymptomatic period of exposure to 1, 2 and 3 atmospheres absolute of oxygen. Torbati, D., Lambertsen, C.J., Greenberg, J. Neuroscience (1984) [Pubmed]
  13. Changes in the expression of the extracellular matrix molecules tenascin-C and tenascin-R after 3-acetylpyridine-induced lesion of the olivocerebellar system of the adult rat. Wintergerst, E.S., Bartsch, U., Batini, C., Schachner, M. Eur. J. Neurosci. (1997) [Pubmed]
  14. Retinoic acid influences the development of the inferior olivary nucleus in the rodent. Yamamoto, M., Fujinuma, M., Hirano, S., Hayakawa, Y., Clagett-Dame, M., Zhang, J., McCaffery, P. Dev. Biol. (2005) [Pubmed]
  15. Experimental evidence for climbing fibers in the avian cerebellum. Freedman, S.L., Voogd, J., Vielvoye, G.J. J. Comp. Neurol. (1977) [Pubmed]
  16. Early climbing fiber interactions with Purkinje cells in the postnatal mouse cerebellum. Mason, C.A., Christakos, S., Catalano, S.M. J. Comp. Neurol. (1990) [Pubmed]
  17. Localization of sepiapterin reductase in the human brain. Ikemoto, K., Suzuki, T., Ichinose, H., Ohye, T., Nishimura, A., Nishi, K., Nagatsu, I., Nagatsu, T. Brain Res. (2002) [Pubmed]
  18. Differential expression of voltage-gated potassium channel genes in auditory nuclei of the mouse brainstem. Grigg, J.J., Brew, H.M., Tempel, B.L. Hear. Res. (2000) [Pubmed]
  19. Calcium-binding proteins and GABA reveal spatial segregation of cell types within the developing lateral superior olivary nucleus of the ferret. Henkel, C.K., Brunso-Bechtold, J.K. Microsc. Res. Tech. (1998) [Pubmed]
  20. Identification and distribution of mouse carboxypeptidase A-6. Fontenele-Neto, J.D., Kalinina, E., Feng, Y., Fricker, L.D. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  21. What may be the anatomical basis that secretin can improve the mental functions in autism? Köves, K., Kausz, M., Reser, D., Horváth, K. Regul. Pept. (2002) [Pubmed]
  22. Over-expression of corticotropin-releasing factor mRNA in inferior olivary neurons of rolling mouse Nagoya. Sawada, K., Kawano, M., Tsuji, H., Sakata-Haga, H., Hisano, S., Fukui, Y. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  23. Ethanol increases single unit activity in the inferior olivary nucleus. Rogers, J., Madamba, S.G., Staunton, D.A., Siggins, G.R. Brain Res. (1986) [Pubmed]
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